Publications:

Brown, S. J., Cole, M. D., and Erives, A. J. (2007) The Myc Proto-oncogene Coordinates a Highly Conserved Growth Regulon Across Holozoa. Submitted

Cowling, V. H. and Cole, M. D. (2007) An N-Myc truncation analogous to c-Myc-S induces cell proliferation independently of transactivation but dependent on Myc Homology Box II. Oncogene, in press.

Goodliffe, J. M., Cole, M. D., and Wieschaus, E. (2007) The Trithorax Group Protein Ash1 Works as a Repressor and Activator of Myc Targets. BMC Mol. Biol., 8:40. Abstract

Cowling, V. H., D’Cruz, C. M., Chodosh, L. A., and Cole, M. D. (2007) c-myc transforms human mammary epithelial cells through repression of the Wnt pathway inhibitors DKK1 and SFRP1. Mol. Cell. Biol. 27, 5135-5146. Abstract

Cowling, V. H. and Cole, M. D. (2007) HATs Off to Capping: A New Mechanism for Myc. Cell Cycle 6, 907-909. Abstract

Cowling, V. H. and Cole, M. D. (2007) The Myc transactivation domain promotes global phosphorylation of the RNA pol II carboxy-terminal domain independently of direct DNA binding. Mol. Cell. Biol. 27, 2059-2073. Abstract

Li, H., Cherukuri1, P., Cowling, V., Spinella, M., Cole, M., Godwin, A. K., Wells, W., and DiRenzo, J. (2007) Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors, Cancer Res. 67, 501-510. Abstract

Cowling, V. H. and Cole, M. D. (2007) E-Cadherin repression contributes to c-Myc induced epithelial cell transformation. Oncogene 26, 3582-3586. Abstract

Rickards, B. B., Flint, S. J., Cole, M. D., and LeRoy, G. T. (2007) Nucleolin is required for RNA polymerase I transcription in vivo. Mol. Cell. Biol. 27, 937-948. Abstract

Cole, M. D. and Henriksson, M. (2006) 25 Years of the c-Myc Oncogene. Invited editors. Semin Cancer Biol, 16, 241. Abstract

Cowling, V. H. and Cole, M. D. (2006) Mechanism of Transcriptional Activation by the Myc Oncoproteins. Semin Cancer Biol, 16, 242-252. Abstract

Cowling, V. H., Chandriani, S., Whitfield, M. L., and Cole, M. D. (2006) A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation and G2 arrest Mol. Cell. Biol. 26, 4226-4239. Abstract

Goodliffe, J. M., Wieschaus, E., and Cole, M. D. (2005) Polycomb Mediates Myc Autorepression and its Transcriptional Control of Many Loci in Drosophila. Genes Dev. 19, 2941-2946. Abstract

LeRoy, G., Carroll, R., Kyin, S., Seki, M., and Cole, M.D. (2005) Identification of RecQL1 as a Holliday Junction Processing Enzyme in Mammalian Cells. Nuc. Acids Res. 33, 6251-6257. Abstract

Nikiforov, M. A., N. Popov, Kotenko, I., Henriksson, M., and Cole, M. D. (2003) The Myc and Mad basic domains are functionally equivalent. J. Biol. Chem. 278, 11094-11099. Abstract

Kenny, A. M., Cole, M. D., and Rowitch, D. H. (2003) Nmyc1 upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 130, 15-28. Abstract

Nikiforov, M. A., Chandriani, S., O’Connell, B., Petrenko, O., Kotenko, I., Beavis, A., Sedivy, J. M., and Cole, M. D. (2002) A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of one-carbon unit for cell metabolism. Mol. Cell. Biol. 22, 5793-5800. Abstract

Dugan, K. A., Wood, M. A., and Cole, M. D. (2002) TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis. Oncogene 21, 5835-5843. Abstract

Nikiforov, M. A., Chandriani, S., Park, J., Kotenko, I., Matheos, D., Johnsson, A., McMahon, S. B., and Cole, M. D. (2002) TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol. Cell. Biol. 22, 5054-5063. Abstract

Obaya, A. J., Kotenko, I., Cole, M. D., and Sedivy, J. M. (2002) The proto-oncogene c-myc acts through the cyclin-dependent kinase (cdk) inhibitor p27Kip1 to facilitate the activation of cdk4/6 and early G1 phase progression. J. Biol. Chem. 277, 31263-31269. Abstract

Yanagisawa, J., Kitagawa, H., Yanagida, M., Wada, O., Ogawa, S., Nakagomi, M., Oishi, H., Yamamoto, Y., Nagasawa, H., McMahon, S. B., Cole, M. D., Tora, L., Takahashi, N., and Kato, S. (2002) Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol. Cell 9, 553-582. Abstract

Vieyra, D., Loewith, R., Scott, M., Bonnefin, P., Boisvert, F., Cheema, P., Pastyryeva, S., Meijer, M., Johnston, R. N., Bazett-Jones, D. P., McMahon, S., Cole, M. D., Young, D., and Riabowol, K., (2002). Human ING1 proteins differentially regulate histone acetylation. J. Biol. Chem., 277, 29832-29839. Abstract

Kulesza, C. A., Van Buskirk, H. A., Cole, M. D., Reese, J. C., Smith, M. M., and Engel, D. A. (2002) Adenovirus E1A function in yeast requires the SAGA histone acetyltransferase complex. Oncogene 21, 1411-1422. Abstract

Park, J., Wood, M. A., and Cole, M. D. (2002) BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol. Cell. Bio. 22, 1307-1316. Abstract

Lang, S. E., McMahon, S. B., Cole, M. D., and Hearing, P. (2001) E2F transcriptional activation requires TRRAP and GCN5 cofactors. J. Biol. Chem. 276, 32627-32634. Abstract

Park, J., Kunjibettu, S., McMahon, S. B., and Cole, M. D. (2001) The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. Genes Dev. 15, 1619-1624. Abstract

Nikiforov, M. A., Kotenko, I., Petrenko, O., Beavis, A., Valenick, L., Lemischka, I., and Cole, M. D. (2000) Complementation of Myc-dependent cell proliferation by cDNA expression library screening.  Oncogene 19, 4828-4831. Abstract

Chang, D., Claassen, G., Hann, S. R., and Cole, M. D. (2000) The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals.  Mol. Cell. Biol. 20, 4309-4319. Abstract

McMahon, S. B., Wood, M., and Cole, M. D. (2000) The c-Myc cofactor TRRAP recruits the histone acetylase hGCN5.  Mol. Cell. Biol. 20, 556-562.  Abstract

Wood, M., McMahon, S. B., and Cole, M. D. (2000) An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc.  Mol. Cell 5, 321-330. Abstract.

Cole, M. D. and McMahon, S. B. (1999) The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation.  Oncogene 18, 2916-2924.  Abstract.

Bush, A., Dugan, K., Mateyak,  M., Obaya, A., Adachi, S., Sedivy, J. and Cole, M. D. (1998) c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets.  Genes Dev. 12, 3797-3802. Abstract.

Sheppard, R. D., Samant, S. A., Rosenberg, M., Silver, L. M., and Cole, M. D. (1998) Transgenic N-myc model for indolent B lymphoma: tumor characterization and analysis of genetic alterations in spontaneous and retrovirally accelerated tumors. Oncogene 17, 2073-2085.  Abstract

Saleh, A., Schieltz, D., Ting, N., McMahon, S., Litchfield, D. W., Yates III, J. R., Lees-Miller, S. P., Cole, M. D., and Brandl, C. J. (1998) TRA1p is a component of the yeast ADA/SPT transcriptional regulatory complexes.  J. Biol. Chem. 273, 26559-26570.  Abstract.

McMahon, S. B., Van Buskirk, H. A., Dugan, K. A., Copeland, T., and Cole, M. D. (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.  Cell 94, 363-374. Abstract.

Yuan, J., Tirabassi, R., Bush, A., and Cole, M. D. (1998) The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX.  Oncogene 17, 1109-1118.  Abstract.

Krause, M., Park, M., Yuan, J., Zhang, J.-M., Harfe, B., Xu, S.-Q., Greenwald, I., Cole, M., Paterson, B., and Fire, A. (1997)  A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development.  Development 124, 2179-2189

Bush, A., Hiromi, Y. and Cole, M. D. (1996)  biparous. A novel bHLH gene expressed in neuronal and glial precursors in Drosophila.  Dev. Biol. 180, 759-772.

Hofmann, T. and Cole, M. D. (1996) The Tal-1/SCL oncogene represses transcriptional activation by other bHLH proteins: implications for cell transformation.  Oncogene 13, 617-624.

Asker, C. E., Magnusson, K. P., Piccoli, S.P., Andersson, K., Klein, G., Cole, M. D., and Wiman, K. G. (1995)  Mouse and rat B-myc share amino acid sequence homology with the c-myc transcriptional activator domain and contain a B-myc specific carboxy terminal region.  Oncogene 11, 1963-1969.

Brough, D. E., Hofmann, T. J., Ellwood, K. B., Townley, R. A. and Cole, M. D. (1995) An essential domain of the c-Myc protein interacts with a nuclear factor that is also required for E1a mediated cell transformation. Mol. Cell Biol. 15, 1536-1544.  Abstract.

Berberich, S. J. and Cole, M. D. (1994) The mdm-2 oncogene is translocated and overexpressed in a murine plasmacytoma cell line expressing wild-type p53. Oncogene 9, 1469-1472.

Armand, P., Knapp, A., Hirsch, A., Wieschaus, E. F. and Cole, M. D. (1994) A novel bHLH protein is expressed in the muscle attachment sites of the Drosophila epidermis. Mol. Cell. Biol. 14, 4145-4154.

Carmeliet, P., Kiekens, L., Schoonjans, L., Ream, B., Van Nuffelen, A., Prendergast, G., Cole, M., Bronson, R., Collen, D., and Mulligan, R. C. (1993) Plasminogen activator inhibitor 1 gene deficient mice. I. Generation by homologous recombination and characterization. J. Clin. Invest. 92, 2746-2755.

Trannoy, E., Manser, T., Cole, M. D., and Daley, M. J. (1993) Monoclonal c-myc transformed macrophage cell lines: I. Heterogeneity in ability to process and present antigen. J. Immunol. 151, 3042-3056.

Berberich, S. J., Espenshade, P. E., Hyde-DeRyschyer, and Cole, M. D. (1992) Max encodes a sequence-specific DNA binding protein and is not regulated by serum growth factors.  Oncogene 7, 775-779.

Berberich, S. J., and Cole, M. D. (1992) Casein kinase II inhibits the DNA binding activity of Max homodimers, but not Myc/Max heterodimers. Genes and Dev. 6, 166-176.

Eccles, M. R., King, F. J. and Cole, M. D. (1992) Oncogenic activation of the platelet-derived growth factor receptor by fusion to the colony stimulating factor-1 receptor in a murine monocyte tumor line. Mol. Cell. Biol. 12, 386-393.

Cole, M. D. (1991) Myc meets its Max. Cell 65, 715-716.