Michael D. Cole

Professor

Come join us at Dartmouth! My lab space is in a newly constructed addition to the Rubin Building in the Norris Cotton Cancer Center. The Cancer Center houses a diverse group of researchers from different departments with an interest in cancer biology and signaling. Hanover, NH is only 2 hours north of Boston and close to the hiking and skiing of the scenic White Mountains.

The molecular basis of cancer and oncogenic transcription factors

Studies of the genetic events involved in the induction of cancer provide an opportunity to define the molecular basis of the disease and to study the regulation and function of important eukaryotic genes that control cell proliferation.  The c-myc gene encodes a transcription factor that is critical for progression through the cell cycle, and mutations that misregulate c-myc are frequently found in human and animal cancers (Diagram).  We are interested in defining the cellular target genes through which c-myc acts and also the nuclear factors that mediate target gene regulation.