Chem 102. Quantum Chemistry

An introduction to the quantum mechanics of molecular systems. Approximate methods for calculating the electronic structure of molecules are discussed. Particular emphasis is placed on molecular orbital methods at the empirical, semi-empirical, and ab-initio levels. Evaluation of such methods for studies of molecular geometry, conformational problems, thermochemical data, and spectroscopic parameters is presented. Other topics considered include the electronic structure of hydrogen bonded systems and of excited states. Methods which include the effects of electron correlation are briefly outlined.

Chem 106. Molecular Structure and Spectra

A study of optical spectroscopy including selected topics from amongst point group theory, vibrational spectra of polyatomic molecules, electronic and vibronic spectra of molecules and rotational spectra.

Chem 108. Chemistry of Macromolecules: Physical Properties and Characterization

An introduction to macromolecular science. Mechanisms of polymerization reactions. Light scattering; thermodynamic and transport properties of macromolecular solutions. Structure-property correlations in amorphous and crystalline polymers.

Chem 109. Chemistry of Macromolecules: Synthesis and Characterization

An introduction to the chemistry of organic polymers. The basic classes of polymeriza­tion will be discussed, with attention to kinetic and mechanistic details. Special emphasis will be placed upon living polymerization techniques and their application toward architec­tural control. Additional content will include, as time permits, topics of current interest such as: polymers in organic synthesis, polymeric assemblies and biomimetic/bioconjugate polymers. For selected topics, key articles from the chemical literature will be discussed.

Chem 123. Graduate Toxicology (Identical to Pharmacology and Toxicology 123)

This course is open to graduate, medical and advanced undergraduate students. It pro­vides an introduction to toxicology as a discipline, with a focus on the molecular basis for toxicity of chemicals in biological systems. Major topics include: principles of cell and molecular toxicology, xenobiotic metabolism, molecular targets of cellular toxicity, genetic toxicology, chemical carcinogenesis, immunotoxicology, neurotoxicology, clinical toxi­cology, and quantitative risk assessment.

Chem 124. Analytical Chemistry and Inorganic Instrumental Analysis (Identical to Earth Sciences 124)

This course is directed towards graduate students planning to use inorganic chemical analysis in their thesis work. The lectures and seminars focus on the theory and application of modern instrumental analysis and analytical chemistry. The theoretical backgrounds for a number of inorganic instrumental analytical methods are given, and examples of their application to problems of interest for analytical chemists working in the fields of earth sci­ence, chemistry, biology and environmental science are presented. The lectures cover ion chromatography, electrochemistry, atomic absorption, inductively coupled plasma optical emission and inductively coupled plasma mass spectrometry. The theory and concepts of analytical chemistry are provided along with statistical tools, uncertainty calculations and data treatment methods useful in analytical chemistry.

Chem 130. Organometallic Chemistry

A study of the structure, bonding, and chemical properties of organometallic compounds of the main group and transition elements. Applications to organic synthesis and homogeneous catalysis will be discussed, and organometallic compounds of the lanthanide and actinide elements may also be discussed.

Chem 131. Topics in Advanced Inorganic Chemistry

Treatment at an advanced level of one or more areas of inorganic chemistry. The subject matter varies from year to year and may include mechanisms of inorganic reactions, methods of structure analysis, chemical applications of group theory, and the chemistry of one or more elements or groups in the periodic table. Offered on a tutorial basis to qualified students.

Chem 132. Inorganic Biochemistry (Identical to Biochemistry 132)

The role of metal ions in biological systems. Topics include metal ion transport, storage and interaction with proteins and nucleic acids; metalloproteins involved in oxygen transport and electron transfer; metalloenzymes involved in activation of oxygen and other substrates; and medicinal, toxicity and carcinogenicity aspects of metals; as well as inorganic model chemistry of bioinorganic systems. Several physical methods, including advanced spectroscopic techniques (EXAFS, Raman, ENDOR and NMR) are introduced and their application to current research on the above topics is considered.

Chem 137. Methods of Materials Characterization (Identical to Physics 128 and Engineering Sciences 137)

This survey course discusses both the physical principles and practical applications of the more common modern methods of materials characterization. It covers techniques of both microstructural analysis (OM, SEM, TEM, electron diffraction, XRD), and microchemical characterization (EDS, XPS, AES, SIMS, NMR, RBS and Raman spectroscopy), together with various scanning probe microscopy techniques (AFM, STM, EFM and MFM). Emphasis is placed on both the information that can be obtained together with the limitations of each technique.

Chem 140. Chemistry Research Colloquia

Colloquia presented to the Department of Chemistry by scientists and educators in the chemistry profession on Thursdays, and by graduate students and others conducting research in chemistry and allied fields on Wednesdays as needed. The course is required of all graduate students in chemistry in each term.

Chem 151. Physical Organic Chemistry

Modern theories of organic reaction mechanisms, particularly the use of physical-chemical principles to predict the effect of changing reaction variables, especially reactant structures, on reactivity. The structure, stability, and reactivity of carbanions and carbocations, as well as SN1 and SN2 reactions, are discussed.

Chem 152. Advanced Organic Synthesis and Mechanisms

Consideration of organic chemical reactions at an advanced level. Current knowledge concerning synthetic methods, reaction mechanisms, reactive intermediates, conformational analysis, and biosynthesis are discussed in the context of modern organic chemistry.

Chem 153. Chemistry of Natural Products

A survey of the application of modern synthetic methods to the total synthesis of natural products. Coverage will include retrosynthetic analysis and synthetic planning and an overview of the preparation of a wide variety of important natural products. Emphasis will be placed on student problem-solving in the context of the synthesis of complex molecules.

Chem 157. Topics in Advanced Organic Chemistry

Treatment at an advanced level of one or more areas of organic chemistry. The subject matter may vary from offering to offering; accordingly, the course may be taken for credit more than once.

Chem 159. Chemistry of Heterocyclic Compounds

An introduction to the chemical, physical, and spectroscopic properties of heterocyclic compounds. Coverage will include reactions, synthesis, stereo-chemistry, and unusual rearrangements. Attention will also be given to natural product synthesis and to heterocycles of biological interest.

Chem 161. Topics in Advanced Biophysical Chemistry

Treatment at an advanced level of one or more areas of biophysical chemistry. The subject matter varies from offering to offering; accordingly the course may be taken for credit more than once.

Chem 256. Graduate Instruction in Teaching

A course in the methodology and practice of chemistry teaching at the undergraduate college level. Topics such as laboratory supervision and safety, grading issues, special needs students, lecturing and tutoring techniques, exam preparation, and the teacher/student relationship will be discussed through readings, class discussions, and student presentations. This course is a prerequisite to the supervised undergraduate teaching requirement for the Ph.D. degree in chemistry.

Chem 257. Supervised Undergraduate Teaching in Chemistry

Teaching in chemistry undergraduate courses under the supervision of a faculty member. Normally students enrolled in this course teach alongside faculty in undergraduate instruc-tional laboratories. This course is open only to graduate students; it may be elected for credit more than once.

Chem 260-264. Graduate Research Colloquium in Chemistry

These courses are available to graduate students during each term of residence, including summer. An essential element of scientific training is in the critical analysis and communication of experimental research in an oral format. Evaluation will be based on quality of the work, quality of critical analysis, and on presentation style, including effective use of audiovisual materials. All enrolled students will make oral presentations that describe work from the current literature or their own research.

     Chemistry 260: Organometallic Chemistry

     Chemistry 261: Materials Chemistry

     Chemistry 262: Synthetic Organic Chemistry

     Chemistry 263: Bioinorganic Chemistry

     Chemistry 264: Biophysical Chemistry

Chem 297. Graduate Investigation in Chemistry A

An original and individual experimental or theoretical investigation beyond the undergraduate level in one of the fields of chemistry. This course is open only to graduate students; it may be elected for credit more than once. This course carries one course credit and should be elected by students conducting research and also electing two or more other graduate or undergraduate courses.

Chem 298. Graduate Investigation in Chemistry B

An original and individual experimental or theoretical investigation beyond the undergraduate level in one of the fields of chemistry. This course is open only to graduate students; it may be elected for credit more than once. This course carries two course credits and should be elected by students electing only departmental colloquia in addition to research.

Chem 299. Graduate Investigation in Chemistry C

An original and individual experimental or theoretical investigation beyond the undergraduate level in one of the fields of chemistry. This course is open only to graduate students; it may be elected for credit more than once. This course carries three course credits and should be elected by students conducting research exclusively in any one term.