PPT Slide
Genes Involved in Carcinogenesis
Oncogenes
Tumor Suppressor Genes
Risk of oral cancer from EtOH --The influence of ADH genotype
The Accumulation of Genetic Changes Underlies the Development and Progression of Cancer
Human Genome Project--1990-present
Microsatellites--A class of repetitive DNA scattered throughout the genome
PCR-based Allelotyping using Microsatellites
Relative Proporation and Case Load--of Hereditary Cancers in the USofA
Mechanisms Leading to Loss of the Remaining Normal Allele -- End Result is Loss of Heterozygosity
Loss of Heterozygosity--“LOH”
Familial Risk for Colorectal Cancer--A Function of the Age of the Affected Relative
Causes of Hereditary--Susceptibility to CRC
Risk of Colorectal Cancer (CRC)
Contribution of Gene Mutations to HNPCC Families
Age-Specific Penetrance
Cancer Risks in HNPCC
Risk of metachronous cancer after colon cancer in HNPCC
Breast Cancer Susceptibility Genes
Age-specific Penetrance of Germline BRCA1 mutations
Effect of Oral Contraceptives on Risk of Breast Cancer in Mutation Carriers of BRCA1 or 2
Cumulative incidence of second cancers in hereditary retinoblastoma
The Potential of Genetic Testing--Knowledge is Power
Caveats in Genetic Testing