Computational Biology Journal Club
Biology 270 - Spring 2012

(meets with Genetics 270, Quantitative Biomedical Sciences Seminar Series, Krissy Pattin, co-director)

Location: LSC 352 Time: Wednesdays, 12:00-1:15 Professor: Robert Gross

This journal club involves more discussion and less "presentation." The concept is to have us around a table discussing a paper rather than staring at a screen during a presentation. Although we sometimes choose a specific topic to focus on for the term (suggestions are welcome), this term we will allow any topic that uses computational approaches to address biological problems. We intend to focus on both the theory and practice, while examining applications to biological and biomedical research. We are looking for participants with various backgrounds and interests to add unique perspectives, particularly to the practice and practicality of these methods. By having a cross section of both potential method developers and method users, we will gain a better understanding of the what new methods bring to the table as well as what potential stumbling blocks stand in the way of their successful application.

The individual choosing the paper should prepare a presentation of the paper, which should include a brief discussion of the significance of the paper. It should also include a description of the methods used. The presenter should be prepared to lead the discussion. If slides are needed to illustrate some of the methods (especially those from previous papers or supplementary material), this is appropriate.

Members of the journal club are expected to come with questions about the paper. These questions can focus on methods and discussion and interpretation of the results and their implications.

Note that free lunch will be provided each week. To keep things manageable, it will be the responsibility of the speaker to order the lunch for the journal club on the week that she/he is presenting. Details will be provided by Prof. Gross each term on how this works.

previous terms: 2002F, 2002S, 2003W, 2003S, 2003F, 2004W, 2004S, 2004F, 2005W, 2005S, 2005F, 2006W, 2006S, 2006F, 2007W, 2007S, 2007F, 2008W, 2008S, 2008F, 2009W, 2009S, 2009F, 2010W, 2010S, 2010F, 2011W, 2011S, 2011F, 2012W

mutual information discussion by Chris Langmead [PDF]

mathematical symbols - definitions       algorithms - Wikipedia entries

Date Presenter Paper
Apr 4 TBA TBA
Apr 11 Dov Pechenick "Network Evolution: Rewiring and Signatures of Conservation in Signaling" by Mark G. F. Sun, Martin Sikora, Michael Costanzo, Charles Boone, Philip M. Kim; PLoS Comput Biol 8(3): e1002411 (2012) [PDF]
Apr 18 Rishika De "Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis" by Lisa Pham, Lisa Christadore, Scott Schaus, and Eric D. Kolaczyk; PNAS 108(32):13347–13352 (2011) [PDF]
Apr 25 Rob Frost "Integrative Analysis of Many Weighted Co-Expression Networks Using Tensor Computation" by Wenyuan Li, Chun-Chi Liu, Tong Zhang, Haifeng Li, Michael S. Waterman, Xianghong Jasmine Zhou; PLoS Comput Biol 7(6): e1001106 (2011) [PDF]
May 2 Neil Margulis ‘‘Guilt by Association’’ Is the Exception Rather Than the Rule in Gene Networks" by Jesse Gillis, Paul Pavlidis; PLoS Comput Biol 8(3): e1002444 (2012) [PDF]
May 9 Qinxin Pan "Multidimensional Optimality of Microbial Metabolism" by Robert Schuetz, Nicola Zambon, Mattia Zampieri, Matthias Heinemann, Uwe Saue; Science 336:601 (2012) [PDF]
May 16 Matt Davis "Activation of Inflammation/NF-jB Signaling in Infants Born to Arsenic-Exposed Mothers" by Rebecca C. Fry and many others; PLoS Genet 3(11): e207 (2007) [PDF]
May 23 Jackie Taroni "Three-dimensional reconstruction of protein networks provides insight into human genetic disease" by Xiujuan Wang, Xiaomu Wei, Bram Thijssen, Jishnu Das, Steven M Lipkin & Haiyuan Yu; Nature Biotechnology 30(2): 159 (2012) [PDF]
May 30 Byoung Gug Kwon TBA