Tissue Microarray Technology:

Correlative Science Bridging Array Technology and Clinical Significance

A Report Prepared for Genetics 144: Oncogenomics, February 7, 2005

Darmouth Medical School

Michael Gleeson

Report Outline

Tissue Microarray Background
 
Fundamentals of TMA
Advantages and Limitations of Tissue Microarray
Applying TMA to Cancer Research


Review of: Jacquemier, J., C. Ginestier, et al. (2005). Cancer Res 65(3): 767-79.,

Marseille Study Design
Marseille TMA Study Design: Protein Scoring
Tumor Clusters Identified by Unsupervised Hierarchical Analyses
Patient Subclasses Identified by Tumor Cluster Expression from Unsupervised Hierarchical Analyses: Correlation with 5-year Metastasis-Free Survival
Evaluation of the Marseille "21 Protein Discriminator Set"

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