1979-1980 Connecticut State Scholar
1979-1983 National Merit Scholar
1988-1992 Program in Cancer Biology trainee of the NCI
1993-1996 Fellow of the Leukemia Society of America
1994 Leukemia Society of America Short-Term Scientific Exchange Award
1998 Organizer of Wesleyan University Alumni Symposium on Biology and the New Pharmacopaeia
1998-2000 Basil O'Connor Scholar of the March of Dimes Birth Defects Foundation
1998-2000 Beckman Young Investigator of the Arnold and Mabel Beckman Foundation
1998-2001 Burroughs Wellcome Fund New Investigator in the Basic Pharmacological Sciences
2004-present F04B, Biophysical and Biochemical Sciences Fellowship Study Section, National Institutes of Health
2004 Structural Biology Program, Department of Energy
2005-2007 Beckman Young Investigator Review Committee, Arnold and Mabel Beckman Foundation
2007 William E.M. Lands Lecturer in Nutritional Biochemistry, University of Michigan
2008 American Federation for Aging Research National Scientific Advisory Council
2008-present ICP1, International Cooperative Projects Study Section, National Institutes of Health

Professional Experience

1983-1985 Research Associate for Anthony J. Brake
Chiron Corporation
Emeryville, CA

1986-1988 Research Associate for Kunihiro Matsumoto
DNAX Research Institute
Palo Alto, CA

1996-2000 Assistant Professor of Microbiology & Immunology
Jefferson Medical College
Member, Program in Structural Biology, Kimmel Cancer Center
Thomas Jefferson University
Philadelphia, PA

2000-2003 Associate Professor of Microbiology & Immunology
Jefferson Medical College
Director, Structural Biology & Bioinformatics Program, Kimmel Cancer Center
Thomas Jefferson University
Philadelphia, PA

2003-2007 Associate Professor of Genetics and of Biochemistry
Dartmouth Medical School

2003-2008 Director, Cancer Mechanisms Program
Norris Cotton Cancer Center

2005-present Scientific Director
Comprehensive Thoracic Oncology Program
Dartmouth-Hitchcock Medical Center

2007-present Professor of Genetics and of Biochemistry
Dartmouth Medical School

2008-present Associate Director of Basic Sciences
Norris Cotton Cancer Center
Lebanon, NH

Teaching

1997-2003 Yeast Transformation section of BI532
1997-2003 X-ray Crystallography section of PR613 including the Difference Patterson Function
1999-2003 Yeast Genetics section of GE611
1999-2003 Yeast Cell Cycle and Cell Cycle Checkpoints section of GE636
2004-present NAD+ Metabolism section of the MCB Core Course
2005-present Genetics 144, Oncogenomics
2005-2007 Yeast Genetics section of the MCB Core Course
2007-present Protein Structure and Function section of the PEMM Core Course

Editorial

Founding Editorial Board (with Peter Goodfellow and Gregory Petsko), Genome Biology
Faculty Member, Section on Chemical Biology of the Cell, Faculty of 1000
Editor, with David Duggan, Oncogenomics: Molecular Approaches to Cancer, John Wiley & Sons, 2004

Professional Societies

American Association for the Advancement of Science
American Society for Biochemistry and Molecular Biology
American Association for Cancer Research
American Chemical Society

Publications

1. A. Brake, C. Brenner, R. Najarian, P. Laybourn & J. Merryweather, "Structure of Genes Encoding Precursors of the Yeast Peptide Mating Pheromone a-Factor" in Protein Transport and Secretion, M. J. Gething, ed., pp. 103-108 (1985). Download pdf reprint.

2. I. Miyajima, M. Nakafuku, N. Nakayama, C. Brenner, A. Miyajima, K. Kaibuchi, K. Arai, Y. Kaziro & K. Matsumoto, " GPA1, A Haploid-Specific Essential Gene, Encodes a Yeast Homolog of Mammalian G Protein Which May Be Involved in Mating Factor Signal Transduction," Cell, v. 50, pp. 1011-1019 (1987). Download pdf reprint.

3. C. Brenner, N. Nakayama, M. Goebl, K. Tanaka, A. Toh-e & K. Matsumoto, "CDC33 Encodes mRNA Cap-Binding Protein eIF-4E of Saccharomyces cerevisiae," Mol Cell Biol, v. 8, pp. 3556-3559 (1988). Download pdf reprint.

4. K. Matsumoto, M. Nakafuku, N. Nakayama, I. Miyajima, K. Kaibuchi, A. Miyajima, C. Brenner, K. Arai & Y. Kaziro, "The Role of G Proteins in Yeast Signal Transduction," Cold Spring Harbor Symp Quant Biol, v. 53, pp. 567-575 (1988). Download pdf reprint.

5. R.S. Fuller, C. Brenner, P. Gluschankof & C.A. Wilcox, "The Yeast Prohormone-Processing Kex2 Protease, an Enzyme with Specificity for Paired Basic Residues," in Methods in Protein Sequence Analysis, Jornvall, H., Hoog, J.-O. & Gustavsson, A.-M., pp. 205-214 (1991). Download pdf reprint.

6. C. Brenner & R.S. Fuller, "Structural and Enzymatic Characterization of a Purified Prohormone-Processing Enzyme: Secreted, Soluble Kex2 Protease," Proc Natl Acad Sci, v. 89, pp. 922-926 (1992). Download pdf reprint.

7. H. Angliker, P. Wikstrom, E. Shaw, C. Brenner & R.S. Fuller, "The Synthesis of Inhibitors of Processing Proteases and Their Action on the Kex2 Protease of Yeast," Biochem J, v. 293, pp. 75-81 (1993). Download pdf reprint.

8. C. Brenner, A. Bevan & R.S. Fuller, "One-Step Site-Directed Mutagenesis of The Kex2 Protease Oxyanion Hole," Current Biology, v. 3, pp. 498-506 (1993). Download pdf reprint.

9. C. Brenner, A. Bevan & R. S. Fuller, "Methods for Analyzing the Specificity and Activity of a Prohormone-Processing Enzyme, the Yeast Kex2 Protease (Kexin)," Meth Enz, v. 244, pp. 152-167 (1994). Download pdf reprint.

10. C. Brenner, "Reducing the Energy Barrier to Crystallization, review of Crystallization of Nucleic Acids and Proteins," Protein Science, v. 3, pp. 2471-2472 (1994). Download pdf reprint.

11. H. Diefenbach-Jagger, C. Brenner, B.E. Kemp, W. Baron, J. McLean, T.J. Martin & J.M. Moseley, "Arg21 is the Preferred Kexin Cleavage Site in Parathyroid-Hormone-Related Protein," Eur J Biochem, v. 229, pp. 91-98 (1995). Download pdf reprint.

12. C. Brenner, P. Garrison, J. Gilmour, D. Peisach, D. Ringe, G.A. Petsko & J.M. Lowenstein, "Crystal Structures of Hint Demonstrate that Histidine Triad Proteins are GalT-related Nucleotide-Binding Proteins," Nature Structural Biology, v. 4, pp. 231-238 (1997). View Hint-GMP, Hint-Adenosine, Hint-8-Br-AMP, Apo-Hint entries at the Protein Data Bank. Download pdf reprint.

13. C. Brenner, H.C. Pace, P.N. Garrison, A.K. Robinson, A. Rosler, X.H. Liu, G.M. Blackburn, C.M. Croce, K. Huebner & L.D. Barnes, "Purification and Crystallization of Complexes Modeling the Active State of the Fragile Histidine Triad Protein," Protein Engineering, v. 10, pp. 1461-1463 (1997). Download pdf reprint.

14. G.M. Blackburn, X. Liu, A. Rosler & C. Brenner, "Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P1,P3-triphosphate for Studies with Fhit, the Human Fragile Histidine Triad Protein," Nucleosides and Nucleotides, v. 17, pp. 301-308 (1998). Download pdf reprint.

15. H.C. Pace, P.N. Garrison, A.K. Robinson, L.D. Barnes, A. Draganescu, A. Rosler, G.M. Blackburn, Z. Siprashvili, C.M. Croce, K. Huebner & C. Brenner, "Genetic, Biochemical and Crystallographic Characterization of Fhit-Substrate Complexes as the Active Signaling Form of Fhit," Proc Natl Acad Sci, v. 95, pp. 5484-5489 (1998).  View Fhit-IB2, Fhit H96N-IB2 entries at the Protein Data Bank. Download pdf reprint.

16. Y. Pekarsky, M. Campiglio, Z. Siprashvili, T. Druck, Y. Sedkov, S. Tillib, A. Draganescu, P. Wermuth, J.H. Rothman, K. Huebner, A.M. Buchberg, A. Mazo, C. Brenner, C.M. Croce, "Nitrilase and Fhit Homologs are Encoded as Fusion Proteins in Drosophila melanogaster and Caenorhabditis elegans," Proc Natl Acad Sci, v. 95, pp. 8744-8749 (1998). Download pdf reprint.

17. A. Bevan, C. Brenner & R.S. Fuller, "Quantitative Assessment of Enzyme Specificity in vivo: P₂ Recognition by Kex2 Protease Defined in a Genetic System," Proc Natl Acad Sci, v. 95, pp. 10384-10389 (1998). Download pdf reprint.

18. X. Liu, C. Brenner, A. Guranowski, E. Starzynska & G.M. Blackburn, "New Tripodal, 'Supercharged Analogs' of Adenosine Nucleotides: Inhibitors for the Fhit Ap₃A Hydrolase," Angew Chem Int Ed, v. 38, pp. 1244-1247 (1999). Download pdf reprint (set printer for A4 layout and/or "Shrink To Fit").

19. C. Brenner, "Fhit-Substrate Complexes: A New Paradigm in Reversible Protein Phosphorylation," Proceedings of the XIVth International Conference on Phosphate Chemistry, Phosphorus, Sulfur and Silicon, v. 144-146, pp. 745-748 (1999). Download pdf reprint.

20. K. Huebner, G. Sozzi, C. Brenner, M.A. Pierotti & C.M. Croce, "Fhit Loss in Lung Cancer: Diagnostic and Therapeutic Implications," Advances in Oncology, v. 15, pp. 3-10 (1999). Download pdf reprint (9.2 MB file).

21. M.J. Fernandes, A.A. Finnegan, L.D. Siracusa, C. Brenner, N.N. Iscove & B. Calabretta, "Characterization of a Novel Receptor that Maps Near the Natural Killer Gene Complex: Demonstration of Carbohydrate Binding and Expression in Hematopoietic Cells," Cancer Research, v. 59, pp. 2709-2717 (1999). Download pdf reprint.

22. C. Brenner, P. Bieganowski, H.C. Pace & K. Huebner, "The Histidine Triad Superfamily of Nucleotide-Binding Proteins," J Cellular Physiology, v. 181, pp. 179-187 (1999). Download pdf reprint. Please see ref. 38 for the most current review on HIT proteins.

23. A. Draganescu, S.C. Hodawadekar, K.R. Gee & C. Brenner, "Fhit-Nucleotide Specificity Probed with Novel Fluorescent and Fluorogenic Substrates," J Biol Chem, v. 275, pp. 4555-4560 (2000). Download pdf reprint. The reagents can be ordered from Molecular Probes, Inc.

24. C. Brenner, "A Cultivated Taste for Yeast," Genome Biology, v. 1, pp. reviews103.1-103.4 (2000). Download pdf reprint.

25. C. Brenner, "Fhitness and Cancer in the Mouse," Trends in Genetics, v. 16, p. 294 (2000). Download pdf reprint.

26. H.C. Pace, S.C. Hodawadekar, A. Draganescu, J. Huang, P. Bieganowski, Y. Pekarsky, C.M. Croce & C. Brenner, "Crystal Structure of the Worm NitFhit Rosetta Stone Protein Reveals a Nit Tetramer Binding Two Fhit Dimers," Current Biology, v. 10, pp. 607-617 (2000). View NitFhit at the Protein Data Bank. Download pdf reprint. 

27. C. Brenner, "Condensing the RNA World," Trends in Biochemical Sciences, v. 25, p. 485 (2000). Download pdf reprint.

28. J.R. Boyne, H.M. Yosuf, P. Bieganowski, C. Brenner & C. Price, "Yeast Myosin Light Chain, Mlc1p, Interacts with Both IQGAP and Class II Myosin to Effect Cytokinesis," J Cell Science, v. 113, pp. 4533-4543 (2000). Download pdf reprint.

29. H.C. Pace & C. Brenner, "The Nitrilase Superfamily: Classification, Structure and Function," Genome Biology, v. 2, pp. reviews0001.1-0001.9 (2001). Download pdf reprint. See supplemental data file at Genome Biology.

30. L. Daheron, T. Zenz, L.D. Siracusa, C. Brenner & B. Calabretta, "Molecular Cloning of Ian4: a BCR/ABL-Induced Gene that Encodes an Outer Membrane Mitochondrial Protein with GTP-Binding Activity," Nucleic Acids Research, v. 29, pp. 1308-1316 (2001). Download pdf reprint.

31. A.G. McLennan, L.D. Barnes, G.M. Blackburn, C. Brenner, A. Guranowski, A.D. Miller, J.M. Rovira, P. Rotllan, B. Soria, J.A. Tanner & A. Sillero, "Recent Developments in the Study of the Intracellular Function of Diadenosine Polyphosphates," Drug Development Research, v. 52, pp. 249-259 (2001). Download pdf reprint.

32. J.M. Varnum, J. Baraniak, R. Kaczmarek, W.J. Stec & C. Brenner, "Di-, Tri- and Tetra-5-O-Phosphorothioadenosyl Substituted Polyols as Inhibitors of Fhit: Importance of the Alpha-Beta Bridging Oxygen and Beta Phosphorus Replacement," BMC Chemical Biology, v. 1, 3 (2001). Download pdf reprint.

33. C. Brenner, "FHIT" in the Wiley Encyclopedia of Molecular Medicine, v. 2, Thomas E. Creighton, Ed., pp. 1274-1275 (2001). Download pdf reprint.

34. D.H. Klaubert, K.R. Gee & C.M. Brenner, "Phosphate-Bound Polyazaindacene Derivatives of Nucleotides," US Patent 6,323,186, issued November 27, 2001. Download pdf reprint.

35. S.K. Milano, H.C. Pace, Y.-M. Kim, C. Brenner & J. Benovic, "Scaffolding Functions of Arrestin-2 Revealed by Crystal Structure and Mutagenesis," Biochemistry, v. 41, pp. 3321-3328 (2002).  View Arrestin-2 at the Protein Data Bank. Download pdf reprint.

36. P. Bieganowski, P.N. Garrison, S.C. Hodawadekar, G. Faye, L.D. Barnes & C. Brenner, "Adenosine Monophosphoramidase Activity of Hint and Hnt1 Supports Function of Kin28, Ccl1 and Tfb3," J Biol Chem, v. 277, pp. 10852-10860 (2002). Download pdf reprint.

37. M. Rubio-Texeira, J.M. Varnum, P. Bieganowski & C. Brenner, "Control of Dinucleoside Polyphosphates by the FHIT-Homologous HNT2 Gene, Adenine Biosynthesis, and Heat Shock in Saccharomyces cerevisiae," BMC Molecular Biology, v. 3, 7 (2002). Download pdf reprint.

38. C. Brenner, "Hint, Fhit and GalT: Function, Structure, Evolution and Mechanism of Three Branches of the Histidine Triad Superfamily of Nucleotide Hydrolases and Transferases," Biochemistry, v. 41, pp. 9003-9014 (2002). Download pdf reprint.

39. C. Brenner, "Catalysis in the Nitrilase Superfamily," Current Opinion in Structural Biology, v. 6, pp. 775-782 (2002). Download pdf reprint.

40. A. Owczarek, R. Kaczmarek, B. Mikolajczyk, E. Wasilewska, D. Korczynski, J. Baraniak, M. Koziolkiewicz, W.J. Stec WJ, & C. Brenner, "Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5'-O-phosphorothioyl)glycerols," Nucleosides, Nucleotides and Nucleic Acids, v. 22, pp. 797-9 (2003).

41. F. Trapasso, A. Krakowiak, R. Cesari, J. Arkles, S. Yendamuri, H. Ishii, A. Vecchione, T. Kuroki, P. Bieganowski, H.C. Pace, K. Huebner, C.M. Croce & C. Brenner, "Designed FHIT Alleles Establish that Fhit-Induced Apoptosis in Cancer Cells is Limited by Substrate-Binding," Proc Natl Acad Sci, v. 100, pp. 1592-1597 (2003). Download pdf reprint.

42. H.C. Pace & C. Brenner, "Feminizing Chicks: A Model for Avian Sex Determination Based on Titration of Hint Enzyme Activity and the Predicted Structure of an Asw-Hint Heterodimer," Genome Biology, v. 4, R18 (2003). Download pdf reprint.

43. P. Bieganowski, H.C. Pace & C. Brenner, "Eukaryotic NAD+ Synthetase Qns1 Contains an Essential, Obligate Intramolecular Thiol Glutamine Amidotransferase Domain Related to Nitrilase," J Biol Chem, v. 278, pp. 33049-33055 (2003). Download pdf reprint.

44. P. Bieganowski & C. Brenner, "The Reported Human NADsyn2 is Ammonia-Dependent NAD+ synthetase from a Pseudomonad," J Biol Chem, v. 278, pp. 33056-33059 (2003). Download pdf reprint.

45. C. Brenner, "Subtleties Among Subtilases: Structural Biology of Kex2 and Furin-Related Prohormone Convertases," EMBO Reports, v. 4, pp. 937-938 (2003). Download pdf reprint.

46. D.A. Kwasnicka, A. Krakowiak, C. Thacker, C. Brenner & S.R. Vincent, " Coordinate Expression of NADPH-Dependent Flavin Reductase, FRE-1, and Hint-Related 7meGMP-Directed Hydrolase, DCS-1," J Biol Chem, v. 278, pp. 39051-39058 (2003). Download pdf reprint.

47. A. Krakowiak, H.C. Pace, G. Michael Blackburn, M. Adams, A. Mekhalfia, R. Kaczmarek, J. Baraniak, W.J. Stec & C. Brenner, "Biochemical, Crystallographic and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors," J Biol Chem, v. 279, pp. 18711-18716 (2004). View Hint-N-ethylsulfamoyl adenosine at the Protein Data Bank.  Download pdf reprint.

48. C. Brenner, "Precariously on the Cusp of Oncogenomics," chapter 1 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics poster, the site at Wiley, or Amazon. Download pdf book review in the New England Journal of Medicine.

49. T.M. Maiolatesi & C. Brenner, "Chemical and Genetic Methods to Validate Targets in Non-Mammalian Organisms," chapter 10 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics poster, the site at Wiley, or Amazon. Download pdf book review in the New England Journal of Medicine.

50. P. Bieganowski & C. Brenner, "Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans," Cell, v. 117, pp. 495-502 (2004). Download pdf reprint.

51. P. Bieganowski, K. Shilinski, P.N. Tsichlis & C. Brenner, "Cdc123 and Checkpoint Forkhead Associated With RING Proteins Control the Cell Cycle By Controlling eIF2gamma Abundance, " J Biol Chem, v. 279, pp. 44656-44666 (2004). Download pdf reprint.

52. C. Brenner, "Chemical Genomics in Yeast," Genome Biology, v. 5, 240 (2004). Download pdf reprint.

53. P.M. Clements, C. Breslin, E.D. Deeks, P.J. Byrd, L. Ju, P. Bieganowski, C. Brenner, M.-C. Moreira, A.M.R. Taylor & K.W. Caldecott, "The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4," DNA Repair, v. 3, pp. 1493-1502 (2004). Download pdf reprint.

54. K.P. Parks, H. Seidle, N. Wright, J.B. Sperry, P. Bieganowski, K. Howitz, D.L. Wright & C. Brenner, "Altered Specifity of Hint-W123Q Supports a Role for Hint Inhibition by Asw in Avian Sex Determination," Physiological Genomics, v. 20, pp. 12-14 (2004). Download pdf reprint and supplementary methods and figures.

55. T.-F. Chou, P. Bieganowski, K. Shilinski, J. Cheng, C. Brenner & C.R. Wagner, "³¹P NMR and Genetic Analysis Establish hinT as the only E. coli Purine Nucleoside Phosphoramidase and as Essential for Growth Under High Salt Conditions," J Biol Chem, v. 280, pp. 15356-15361 (2005). Download pdf reprint and supplemental data.

56. H.F. Seidle, P. Bieganowski & C. Brenner, "Disease-Associated Mutations Inactivate AMP-Lysine Hydrolase Activity of Aprataxin," J Biol Chem, v. 280, pp. 20927-20931 (2005). View or download JBC Paper of the Week Summary. Download pdf reprint and supplemental data.

57. C. Brenner, "Evolution of NAD Biosynthetic Enzymes," Structure, v. 13, pp. 1239-1240 (2005). Download pdf reprint.

58. K.L. Bogan & C. Brenner, "Fhit," AfCS-Nature Molecule Pages (2006), [doi:10.1038/mp.a000914.01].

59. S.K. Milano, Y.-M. Kim, F.P. Stefano, J.L. Benovic & C. Brenner, "Nonvisual Arrestin Oligomerization and Cellular Localization are Regulated by Inositol Hexakisphosphate Binding," J Biol Chem, v. 281, pp. 9812-9823 (2006). View Arrestin-2-IP6 entry at the Protein Data Bank. Download pdf reprint and supplementary figures.

60. J. Martin, F. Magnino, K. Schmidt, A.-C. Piguet, J.-S. Lee, D. Semela, M.V. St-Pierre, A. Ziemiecki, D. Cassio, D. Mochly-Rosen, C. Brenner, S.S. Thorgeirsson & J.-F. Dufour, "Hint2, a Mitochondrial Apoptotic Sensitizer Downregulated in Hepatocellular Carcinoma," Gastroenterology, v. 130, pp. 2179-2188 (2006). Download pdf reprint.

61. P. Bieganowski, H.F. Seidle, M. Wojcik & C. Brenner, "Synthetic Lethal and Biochemical Analyses of NAD and NADH Kinases in Saccharomyces cerevisiae Establish Separation of Cellular Functions," J Biol Chem, v. 281, pp. 22439-22445 (2006). Download pdf reprint.

62. A.B. Parsons, A. Lopez, I.E. Givoni, D.E. Williams, C.A. Gray, J. Porter, G. Chua, R. Sopko, R.L. Brost, C.-H. Ho, J. Wang, T. Ketela, C. Brenner, J.A. Brill, G.E. Fernandez, T.C. Lorenz, G.S. Payne, S. Ishihara, Y. Ohya, B. Andrews, T.R. Hughes, B.J. Frey, T.R. Graham, R.J. Andersen & C. Boone, "Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast," Cell, v. 126, pp. 611-6255 (2006). Download pdf reprint. Examine supplementary data.

63. M. Wojcik, H.F. Seidle, P. Bieganowski & C. Brenner, "Glutamine-Dependent NAD+ synthetase: How a Two-Domain, Three-Substrate Enzyme Avoids Waste," J Biol Chem, v. 281, pp. 33395-33402 (2006). Download pdf reprint.

64. P. Belenky, K.L. Bogan & C. Brenner, "NAD+ Metabolism in Health and Disease," Trends in Biochemical Sciences, v. 32, pp. 12-19 (2007). Download pdf reprint.

65. C.L. Linster, T.A. Gomez, K.C. Christensen, L.N. Adler, B.D. Young, C. Brenner & S.G. Clarke, "Arabidopis VTC2 Encodes GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants," J Biol Chem, v. 282, pp. 18879-18885 (2007). Download pdf reprint. View or download JBC Paper of the Week Summary.

66. P. Belenky, F.G. Racette, K.L. Bogan, J.M. McClure, J.S. Smith & C. Brenner, "Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+," Cell, v. 129, pp. 473-484 (2007). Download pdf reprint and supplementary data. Read Leading Edge Preview in Cell, Research Highlights in Nature and Spotlight in ACS Chemical Biology.

67. M.E. Robu, J.D. Larson, A. Nasevicius, S. Beiraghi, C. Brenner, S.A. Farber & S.C. Ekker, "p53 Activation by Knockdown Technologies," PLOS Genetics, v. 3, issue 5, e78 (2007). Download pdf reprint.

68. C. Brenner, "Histidine Triad (HIT) Superfamily," Encyclopedia of Life Sciences, (2007), John Wiley & Sons, Ltd: Chichester.

69. W. Tempel, W.M. Rabeh, K.L. Bogan, P. Belenky, M. Wojcik, H.F. Seidle, L. Nedyalkova, T. Yang, A.A. Sauve, H.-W. Park & C. Brenner, "Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+," PLoS Biology, v. 5, issue 10, e263 (2007). View Nrk1-ADP, Nrk1-NR, Nrk1-AppNHp+NR, Nrk1-NMN, and Nrk1-tiazofurin entries at the Protein Data Bank. Download pdf reprint and supporting information.

70. R.S. Fuller, R.A. Bambara, T. Baker, B. Funnell, E. Wahle, M. O'Donnell, D. Kaiser, K. Skarstad, B. Konforti, S. Maki, T. Katayama, K. Sekimizu, J.H. Weiner, R.W. Davis, L. Rowen, M.F. Goodman, J. Spudich, S. Pfeffer, C.C. Richardson, P. Polaczek, R. Calendar, R. Kolodner, J. Griffith, B. Stillman, P. Modrich, C. Brenner & C. Yanofsky, "A Tribute to Arthur Kornberg, 1918-2007," Nat Struct Mol Biol, v. 15, pp. 2-17 (2008). Download pdf reprint.

71. G.L. Loring, K.C. Christensen, S.A. Gerber & C. Brenner, "Yeast Chfr Homologs Retard Cell Cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-Dependent Ubiquitination," Cell Cycle, v. 7, pp. 95-105 (2008). Download pdf reprint and supplementary information.

72. P.A. Belenky, T.G. Mogu & C. Brenner, "S. cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter, Nrt1," J Biol Chem, v. 283, pp. 8075-8079 (2008). Download pdf reprint and supplementary information.

73. K.L. Bogan & C. Brenner, "Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition," Ann Review Nutrition, v. 28, in press (2008). Download pdf preprint.

74. C.L. Linster, L.T. Adler, K. Webb, K.C. Christensen, C. Brenner & S.G. Clarke, "A Second GDP-L-Galactose Phosphorylase in Arabidopsis en Route to Vitamin C: Covalent Intermediate and Substrate Requirements for the Conserved Reaction," J Biol Chem, v. , in press (2008). Download pdf preprint.

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