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Jian is introducing mutations
into the gene for the Rieske iron-sulfur protein to investigate whether
they increase superoxide anion formation.
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Ember shows off a sample of yeast bc1 complex that was purified by an automated chromatographic procedure. | Carlos Gomez-Lojero, a visiting professor from the National University in Mexico City, is taking spectra of the bc1 complex with inhibitors bound. | |
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| Vincenzo Zara, a visiting professor from Lecce, Italy,is constructing yeast strains in which genes for subunits of the bc1 complex have been deleted. |
Torsten and the fermentation
bottles. It might not be very sophisticated,
but we routinely grow 80 liters of yeast at a time, with no fermentor
malfunctions!
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Jacques is searching a data-base on the Internet with his lap-top. | |
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Nicole, from the Barlowe lab,
hanging out!
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Raul is setting up the rapid
scanning spectrophotometer.
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Nick is synthesizing new inhibitors of the bc1 complex. |
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Laura, a research technician, keeps the lab running smoothly. |
Philip Hill, a student from University
College London, has created mutations in the yeast bc1 complex analagous
to those that confer resistance to atovaquone in Pneumocystis carinii.
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Ben Lange, a research assistant,
is using energy-minimization programs to model inhibitors of the bc1 complex
into the crystal structure of the enzyme.
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