Welcome to the Trumpower lab home page!

	The mechanism by which the cytochrome bc1 complex transfers electrons from ubiquinol to cytochrome c and links this electron transfer to proton translocation is the protonmotive Q cycle, shown above.
This site is intended to introduce you to the research projects in the Trumpower lab and the people who are working on those research projects. I hope you enjoy your "virtual visit," and that you will come visit us in person. Bernard Trumpower ...	The Q cycle implies a transmembrane arrangement of the redox prosthetic groups. This topographical arrangement is confirmed by the location of prosthetic groups in the crystal structures of the bc1 complex, such as that of the yeast enzyme, shown below.
Atovaquone (ATV) bound to the ubiquinol oxidation pocket of the yeast cytochrome bc1 complex. Atovaquone is used to treat Pneumocystis (pneumonia) and Plasmodium (malaria). The drug binds to H181 in the Rieske protein and by a water mediated hydrogen bond to E272 of cytochrome b. The residue L275 is responsible for the differential efficacy of the therapeutic in the fungal versus mammalian enzymes. (From the J. Biol. Chem. cover, vol. 278, No 33, based on work by Kessl and colleagues published in that same issue.)

Research Projects

This folder contains an overview of our research.

Publications

This folder contains PDF files of some of our recent publications. After you download them to your computer you may read them with Adobe Acrobat.

Structures

This folder, which is under construction, contains the coordinates for the crystal structure of the yeast bc1 complex and several views of the enzyme created from the crystal structure. The crystal structure is a PDB file. The views of the enzyme are JPEG files.

Postdoctoral fellows

This folder contains snapshots of the postdoctoral fellows who are currently in the lab. Inquires about postdoctoral positions can be made by e-mail to Trumpower@Dartmouth.edu.

Around the Lab

This folder contains snapshots taken around the lab.

Alumni

This folder contains snapshots of some recent alumni from the lab.