Biophysics at 



The Biophysics research community at Dartmouth draws together faculty from a wide variety of disciplines and departments at the interface between biology, physics, chemistry, and computational methods. Over the past half century, biophysical studies have provided dramatic insights into cellular assembly and dynamics, membrane biology, the organization of genetic information, and the principles governing protein function, reflecting the importance of physical approaches and insights in understanding biological systems. The goal of the program is to support and foster interdisciplinary interactions focused on biologically and medically important problems. Major research areas include:

Faculty associated with the program are drawn from the Departments of Biochemistry, Biology, Chemistry, Computer Science, Engineering, Genetics, Mathematics, Pharmacology&Toxicology, and Physiology and Neurobiology. Many are affiliated with the Graduate Programs in Molecular and Cellular Biology (MCB), Chemistry, and Engineering, and with the Program in Experimental and Molecular Medicine (PEMM). Many are also affiliated with the Institute of Biomolecular Targeting (BioMT), an NIH-funded Center of Biomedical Research Excellence. Students interested in pursuing undergraduate or graduate studies in Biophysics are encouraged to contact the individual faculty members listed below, or to apply to one of the affiliated Departments or Programs.


Margie Ackerman
Engineering, Microbiology & Immunology
Protein engineering and biotherapeutics
Chris Bailey-Kellogg
Computer Science
Algorithms for structural biology and protein engineering
Robert S. Cantor Chemistry Influence of lipids on membrane protein function
Ta Yuan Chang Biochemistry Membrane Enzymology of Acyl-Coenzyme A:Cholesterol Acyltransferase
Duane A. Compton Biochemistry Structural Aspects of Mitosis
Scott A. Gerber Genetics, Biochemistry Structure-function studies of mitotic kinase complexes
Amy S. Gladfelter Biology Single molecule, polarization microscopy of the cytoskeleton and protein aggregates
Gevorg Grigoryan
Computer Science, Engineering
Protein design; specificity of protein-protein recognition
Karl Griswold
Protein engineering and directed evolution
Leslie P. Henderson Physiology and Neurobiology, Biochemistry Steroids and Synapses
Henry N. Higgs Biochemistry Cell Motility of Leukocytes
Arminja Kettenbach Biochemistry Structural and functional proteomics
F. Jon Kull Chemistry Structural mechanisms of cytoskeletal proteins
Dean R. Madden Biochemistry Structural biology of ion-channel regulatory interactions
Jason S. McLellan Biochemistry Structural basis of host-pathogen interactions
Robert A. Maue Physiology and Neurobiology, Biochemistry Ion Channel Regulation
Dale F. Mierke
Structural biology of peptide hormones
Lawrence C. Myers Biochemistry Molecular Mechanisms of Transcriptional Regulation
Kate Pletneva
Protein conformational changes
Brian W. Pogue Engineering Medical physics of optical, molecular and radiation imaging
Michael J. Ragusa Chemistry Structural investigations of vesicle formation during autophagy
Daniel N. Rockmore Mathematics, Computer Science Scientific computation, medical imaging
Roger D. Sloboda Biology Protein-protein interactions, light microscopy
Mark R. Spaller
Pharmacology and Toxicology, Chemistry
Peptide and small-molecule regulators of protein-protein interactions
Dean E. Wilcox Chemistry Interaction of metal ions with proteins and other biological molecules