reference librarian comments, March 2000
| On Doctoring MEDLINE searches, with reference librarian comments, March 2000 |
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The question was
Can administration of antibiotics to children induce asthma later in life?
I also performed a couple of random searches which are included in the history. The answers to my question were found in numbers 7,8, and 10 below.
1 Bipolar disorder/ or Depressive disorder/ results=18573
2 limit 1 to (human and yr=1991-2000) results=18434
3 Drug therapy/ or Self care/ or Self medication/ results=7047
4 1 and 3 results=81
5 Fluoxetine/im [Immunology] results=2
6 Asthma/bl and Asthma/ci and Asthma/pa and Asthma/pc and results=0 Asthma/pp and Asthma/em and Asthma/en and Asthma/ep and
Asthma/et and Asthma/th and Asthma/ge and Asthma/hi and
Asthma/im [Blood, Chemically Induced, Pathology, Prevention
& Control, Physiopathology, Embryology, Enzymology,
Epidemiology, Etiology, Therapy, Genetics, History,
Immunology]
7 Asthma/bl,ci,pa,pc,pp,em,en,ep,et,th,ge,hi,im [Blood, results=13897
Chemically Induced, Pathology, Prevention & Control,
Physiopathology, Embryology, Enzymology, Epidemiology,
Etiology, Therapy, Genetics, History, Immunology]
8 7 and antibiotics.mp. [mp=title, abstract, registry number results=77
word, mesh subject heading]
9 from 8 keep 9-10 results=2
10 from 8 keep 9-10,13,15,22,28,36,45,70 results=9
11 Drosophila/ or Drosophila melanogaster/ results= 14242
12 Dimethyl sulfoxide/ results=2327
13 11 and 12 results=1
14 from 13 keep 1 results=1
15 Bipolar disorder/ or Depressive disorder/ results=18573
16 limit 15 to (human and yr=1991-2000) results=18434
17 Drug therapy/ or Self care/ or Self medication/ results= 7047
18 15 and 17 results= 81
19 Fluoxetine/im [Immunology] results= 2
20 Asthma/bl and Asthma/ci and Asthma/pa and Asthma/pc and results=0
Asthma/pp and Asthma/em and Asthma/en and Asthma/ep and
Asthma/et and Asthma/th and Asthma/ge and Asthma/hi and
Asthma/im [Blood, Chemically Induced, Pathology, Prevention
& Control, Physiopathology, Embryology, Enzymology,
Epidemiology, Etiology, Therapy, Genetics, History,
Immunology]
21 Asthma/bl,ci,pa,pc,pp,em,en,ep,et,th,ge,hi,im [Blood, results=13897
Chemically Induced, Pathology, Prevention & Control,
Physiopathology, Embryology, Enzymology, Epidemiology,
Etiology, Therapy, Genetics, History, Immunology]
22 21 and antibiotics.mp. [mp=title, abstract, registry number results=77
word, mesh subject heading]
23 from 22 keep 9-10 results=2
24 from 22 keep 9-10,13,15,22,28,36,45,70 results= 9
25 Drosophila/ or Drosophila melanogaster/ results=14242
26 Dimethyl sulfoxide/ results= 2327
27 25 and 26 results= 1
28 from 27 keep 1 results= 1
Reference Librarian comments
Yowie! I thought only *I* did searches this long. I'm (quite honestly) glad you were bopping around MEDLINE. Rather than look at it (your strategy) line-by-line, let me say this: Usually, you should "explode" MeSH terms. And frequently I like to check the "focus" check-box, to get fewer and more "on target" references.
Meanwhile, we might want to forget that last suggestion of mine in this case. When I played around a little bit with this topic, I found that I needed all the retrieval I could get. I quickly discovered that I'd better NOT check the "focus" box. This search was fun, for me, because I came so close to thinking: "No. There is no literature at all on the idea of antibiotics, given to children, causing asthma later on."
After more sleuthing, I'm now thinking something like this: "Yes, maybe. Interesting possibility. This is a bran-new 1999 thought. More research will be done. This is not an "internet hoax," (which we get plenty of!). (i.e., does antipersperant cause breast cancer?)
I kept broadening and expanding things, and then I started finding references. Also, sometimes I think the term "asthma" is a little problematic. Maybe like "schizophrenia," or something. It's a "moving target," murky sort of diagnosis, at least to me. What I'm thinking is that one could "broaden" the asthma idea to the larger concept of respiratory diseases in general.
One could do something like this:
a) exp *respiratory diseases/et [Etiology]
b) exp antibiotics/ae, po, to [Adverse effects, Poisoning, Toxicity]
c) 1 and 2But, I didn't do that.
Here below is what I did. I looke through the 57 results from Set # , and selected a few, for your reading enjoyment!
I had one more thought. Given that that article by "Wickens," below, is pretty much "IT" -- it would be interesting to see if anyone has CITED that article in subsequent papers. The trouble is, the article came out in Jun 1999, so people have not had much time to cite the article.
I think I'll try that. I'll go to the Web-of-Science, at:
http://www.dartmouth.edu/~library/wos/
(I'll put the Web of Science results near "°B°" down below.
Another interesting idea is to see what else WICKENS has written. See °C° below. He or she is obviously interested in etiologic aspects of asthma.
Medline 1966 to January 2000
#
Search History
Results
1
exp Asthma/ci,et [Chemically Induced, Etiology]
8315
2
exp Antibiotics/ae,me,po,py,ct,to,ec [Adverse Effects, Metabolism, Poisoning, Pathogenicity,
Contraindications, Toxicity, Economics]
53517
3
1 and 2
574
from 3 keep 2-3,5,20,28,34,44,48,51,53
10
Results of your search (set 6): from 3 [1 and 2] keep 2-3,5,20,28,34,44,48,51,53
Citations available: 10
Citations displayed: 1-10<1>
AN 99268959
AU Wickens K. Pearce N. Crane J. Beasley R.
IN The Wellington Asthma Research Group, Wellington School of
Medicine, Wellington South, Wellington, New Zealand.
TI Antibiotic use in early childhood and the development of
asthma.
SO Clinical & Experimental Allergy. 29(6):766-71, 1999 Jun.
LM Dana. Incomplete holdings, check catalog.
AB BACKGROUND AND OBJECTIVE: Recent investigations have focused on the role of
infections in infancy in promoting or protecting against the subsequent
development of asthma. A related hypothesis concerns the
possible role of medical responses to infections, including the widespread
use of antibiotics. We chose children at Rudolf Steiner
schools to test this latter hypothesis because a significant proportion of
parents rejects the use of conventional treatments, including
antibiotics. METHODS: Seventy-five per cent (n = 456) of
parents of children aged 5-10 years attending Rudolf Steiner schools
throughout New Zealand completed questionnaires which included questions on
the use of antibiotics and a history of
asthma and wheeze in their children. RESULTS: After
controlling for potential confounders, antibiotic use was significantly
associated with having a history of asthma (OR = 2.74, 95%
CI: 1.10-6.85) or wheeze (OR = 1. 86, 95% CI: 1.06-3.26) but not with current
wheeze (OR = 1.08, 95% CI: 0.54-2-16). The adjusted odds ratio for
asthma was 4.05 (95% CI: 1.55-10.59) if
antibiotics were used in the first year of life and 1. 64
(95% CI: 0.60-4.46) if antibiotics had been used only after
the first year of life when compared with children who had never used
antibiotics. The number of courses of
antibiotics during the first year of life was also
associated with increased odds ratios for asthma: 2.27 (95%
CI: 1.14-4.51) for one to two courses and 4.02 (95% CI: 1.57-10.31) for three
or more courses when compared with no antibiotic use in the first year of
life. Although not significant, the association of
antibiotics and hay fever (OR = 1.99 [95% CI: 0. 93-4.26])
was of a similar strength to the association of antibiotics
with a history of wheeze. Antibiotics were not significantly
associated with eczema (OR = 1.23 [95% CI: 0.71-2.13]). CONCLUSION:
Antibiotic use in infancy may be associated with an increased risk of
developing asthma. Further study is required to determine
the reasons for this association.
<2>
AN 99268951
AU Mattes J. Karmaus W.
TI The use of antibiotics in the first year of life and
development of asthma: which comes first? [editorial].
[Review] [32 refs]
SO Clinical & Experimental Allergy. 29(6):729-32, 1999 Jun.
LM Dana. Incomplete holdings, check catalog.
<3>
AN 98151939
AU Jimenez I. Anton E. Picans I. Sanchez I. Quinones MD. Jerez J.
IN Seccion de Alergia, Hospital Marques de Valdecilla, Santander, Spain.
TI Occupational asthma specific to amoxicillin.
SO Allergy. 53(1):104-5, 1998 Jan.
LM Not at Dartmouth/DHMClibraries;request on interlibrary loan.
<4>
AN 86155152
AU White JP. Ward MJ.
TI Drug-induced adverse pulmonary reactions. [Review] [192 refs]
SO Adverse Drug Reactions & Acute Poisoning Reviews. 4(4):183-211, 1985
Winter.
LM Not at Dartmouth/DHMClibraries;request on interlibrary loan.
<5>
AN 81156860
AU Madamba A. Baena-Cagnani CE. Oehling A.
TI Etiological factors in child bronchial asthma.
SO Allergologia et Immunopathologia. 8(6):673-8, 1980 Nov-Dec.
LM Not at Dartmouth/DHMClibraries;request on interlibrary loan.
AB Available statistics regarding the different activating mechanisms of
asthma vary greatly and they are a product of an era wherein
only the extrinsic factors were considered to be fundamental in the etiology
of bronchospasm. For the present study were selected 700 clinical case
histories of children suffering from bronchial asthma.
Emphasis was placed on the sex, age of onset, family history, presence of
associated allergic disorders, intracutaneous tests and their relation to the
anamnesis and evolution of the disease in the treatment period for no less
than three years. A purely bacterial cause, without other types of
sensitization involved, was present in 54% of the cases, on the contrary,
purely extrinsic factors were present in 10% of the cases, summing up to 46%,
if their role in the mixed group is taken into consideration. The high
percentage of bacterial asthma (94.7%) was found
fundamentally in children below one year of age. The results obtained in this
demonstrate the great importance of the bacterial factor in child bronchial
asthma.
<6>
AN 78002390
AU Menon MP. Das AK.
TI Tetracycline asthma--a case report.
SO Clinical Allergy. 7(3):285-90, 1977 May.
LM Dana. Incomplete holdings, check catalog.
AB A mechanic working in the antibiotic capsuling section of a pharmaceutical
company developed asthmatic attacks 1 year after starting
work. His occupation involved exposure to a variety of chemical agents
including tetracycline. He developed immediate weal and flare reaction to the
intradermal test and an immediate (type 1) asthmatic
response to intradermal, inhalation and oral challenge tests with
tetracycline. On leaving the tetracycline plant he became symptom free.
<7>
AN 74063845
AU Smith JM.
TI Incidence of atopic disease. [Review] [63 refs]
SO Medical Clinics of North America. 58(1):3-24, 1974 Jan.
LM Pre-1993 at Dana,1993-date at MFHSL.
<8>
AN 72268972
AU Seropian E. Matei C. Ranga B.
TI [Various aspects of bronchial asthma caused by drugs].
[German]
SO Allergie und Immunologie. 17(3):218-20, 1971.
LM Not at Dartmouth/DHMClibraries;request on interlibrary loan.
<9>
AN 71142234
AU Serra C.
TI [On iatrogenic damage caused by chemoantibiotic therapy of chronic
bronchopneumopathies]. [Italian]
SO Minerva Medica. 62(16):770-5, 1971 Feb 24.
LM Not at Dartmouth/DHMClibraries;request on interlibrary loan.
<10>
AN 70032121
AU Dombrovskaia IuF.
TI [Side effects of antibiotics in pediatrics (drug disease,
drug hypersensitivity in respiratory diseases)]. [Russian]
SO Pediatriia. 48(9):5-11, 1969 Sep.
LM Not at Dartmouth/DHMClibraries;request on interlibrary loan.
°B° (from the Web-of-Science, which lets you see who has CITED certain papers...)
Wickens K, Crane J, Pearce N, et al.
The magnitude of the effect of smaller family sizes on the increase in the prevalence of asthma and hay
fever in the United Kingdom and New Zealand
J ALLERGY CLIN IMMUN 104: (3) 554-558 Part 1 SEP 1999
Mattes J, Karmaus W
The use of antibiotics in the first year of life and development of asthma: which comes first?
CLIN EXP ALLERGY 29: (6) 729-732 JUN 1999
Hopkin JM
Early life receipt of antibiotics and atopic disorder
CLIN EXP ALLERGY 29: (6) 733-734 JUN 1999
°C° (papers by Wickens-K, in Medline, 1966 to present)
Results of your search : Wickens K.au.
Citations available: 6
Citations displayed: 1-6<1>
AN 99414154
AU Wickens K. Crane J. Pearce N. Beasley R.
IN Wellington Asthma Research Group, Department of Medicine, Wellington School
of Medicine, Wellington, New Zealand.
TI The magnitude of the effect of smaller family sizes on the increase in the
prevalence of asthma and hay fever in the United Kingdom and New Zealand.
SO Journal of Allergy & Clinical Immunology. 104(3 Pt 1):554-8, 1999 Sep.
LM Dana. Incomplete holdings, check catalog.
AB BACKGROUND: Declining family size is one factor that has been proposed to
contribute to increasing asthma and hay fever prevalence, but its relative
importance has not been quantified. OBJECTIVE: Our purpose was to determine
the change in asthma and hay fever prevalence that would be expected from the
reduction in family size that has occurred in England/Wales and New Zealand
over recent decades. METHODS: The relative change in family size between 1961
and 1991 in England/Wales and New Zealand was determined from census data for
these years. Summary weighted odds ratios were calculated for the
associations among birth order, family size, and asthma and hay fever
prevalence. The expected increase in the prevalence of asthma and hay fever
between 1961 and 1991 resulting from changes in family size was then
calculated. RESULTS: The expected relative increase in the prevalence of
asthma between 1961 and 1991 as a result of the smaller family size was 1%
and 5% for England/Wales and New Zealand, respectively; smaller family size
would be expected to increase the prevalence of hay fever prevalence in
England/Wales by 4%. CONCLUSIONS: Changes in family size over the last 30
years do not appear to explain much of the reported increase in asthma or hay
fever prevalence. The contribution that other risk factors have made to these
increases could be assessed with use of a similar approach.
<2>
AN 99268959
AU Wickens K. Pearce N. Crane J. Beasley R.
IN The Wellington Asthma Research Group, Wellington School of Medicine,
Wellington South, Wellington, New Zealand.
TI Antibiotic use in early childhood and the development of asthma.
SO Clinical & Experimental Allergy. 29(6):766-71, 1999 Jun.
LM Dana. Incomplete holdings, check catalog.
AB BACKGROUND AND OBJECTIVE: Recent investigations have focused on the role of
infections in infancy in promoting or protecting against the subsequent
development of asthma. A related hypothesis concerns the possible role of
medical responses to infections, including the widespread use of antibiotics.
We chose children at Rudolf Steiner schools to test this latter hypothesis
because a significant proportion of parents rejects the use of conventional
treatments, including antibiotics. METHODS: Seventy-five per cent (n = 456)
of parents of children aged 5-10 years attending Rudolf Steiner schools
throughout New Zealand completed questionnaires which included questions on
the use of antibiotics and a history of asthma and wheeze in their children.
RESULTS: After controlling for potential confounders, antibiotic use was
significantly associated with having a history of asthma (OR = 2.74, 95% CI:
1.10-6.85) or wheeze (OR = 1. 86, 95% CI: 1.06-3.26) but not with current
wheeze (OR = 1.08, 95% CI: 0.54-2-16). The adjusted odds ratio for asthma was
4.05 (95% CI: 1.55-10.59) if antibiotics were used in the first year of life
and 1. 64 (95% CI: 0.60-4.46) if antibiotics had been used only after the
first year of life when compared with children who had never used
antibiotics. The number of courses of antibiotics during the first year of
life was also associated with increased odds ratios for asthma: 2.27 (95% CI:
1.14-4.51) for one to two courses and 4.02 (95% CI: 1.57-10.31) for three or
more courses when compared with no antibiotic use in the first year of life.
Although not significant, the association of antibiotics and hay fever (OR =
1.99 [95% CI: 0. 93-4.26]) was of a similar strength to the association of
antibiotics with a history of wheeze. Antibiotics were not significantly
associated with eczema (OR = 1.23 [95% CI: 0.71-2.13]). CONCLUSION:
Antibiotic use in infancy may be associated with an increased risk of
developing asthma. Further study is required to determine the reasons for
this association.
<3>
AN 98255550
AU D'Souza WJ. Te Karu H. Fox C. Harper M. Gemmell T. Ngatuere M.
Wickens K. Crane J. Pearce N. Beasley R.
IN Wellington Asthma Research Group, Dept of Medicine, Wellington School of
Medicine, New Zealand.
TI Long-term reduction in asthma morbidity following an asthma self-management
programme.
SO European Respiratory Journal. 11(3):611-6, 1998 Mar.
LM Pre-1993 at Dana,1993-date at MFHSL.
AB The adult "credit card" asthma self-management plan has been shown to be an
effective and acceptable system for reducing asthma morbidity when introduced
as part of a 6 month community-based asthma programme. The aim of the present
study was to assess the effectiveness of the credit card plan 2 yrs after the
end of the programme. Markers of asthma morbidity and use of medical services
were compared during the 12 months before enrolment, and 2 yrs after
completing the 6 month asthma programme. Of the 69 participants who
originally enroled in the 6 month asthma programme, 58 were surveyed 2 yrs
after completion of the programme. These participants showed a significant
improvement in all but one of the asthma morbidity measures. The proportion
waking most nights with asthma in the previous 12 months decreased from 29 to
9% (p=0.02), emergency visits to a general practitioner decreased from 43 to
16% (p=0.001), hospital emergency department visits with asthma decreased
from 19 to 5% (p=0.02) and hospital admissions decreased from 17 to 5%
(p=0.04). Only 24% of patients reported that they usually monitored their
peak flow rate daily, but this increased to 73% during a "bad" attack of
asthma. A long-term reduction in asthma morbidity and requirement for acute
medical services can result following the introduction of the adult credit
card asthma self-management plan. Adult patients with asthma are most likely
to undertake peak flow monitoring preferentially during periods of unstable
asthma, rather than routinely during periods of good control.
<4>
AN 98341980
AU Wickens K. Siebers R. Ellis I. Lewis S. Sawyer G.
Tohill S. Stone L. Kent R. Kennedy J. Slater T. Crothall A. Trethowen
H. Pearce N. Fitzharris P. Crane J.
IN Wellington Asthma Research Group, Wellington School of Medicine, New
Zealand.
TI Determinants of house dust mite allergen in homes in Wellington, New
Zealand.
SO Clinical & Experimental Allergy. 27(9):1077-85, 1997 Sep.
LM Dana. Incomplete holdings, check catalog.
AB OBJECTIVES: To measure levels of the major Dermatophagoidespteronyssinus
allergen (Der p 1) in homes in Wellington, New Zealand, and to examine
factors which affect these levels. METHODS: As part of a study of risk
factors for asthma among 474 8-10-year-old children, standard procedures were
used to collect reservoir dust and to measure Der p 1 levels on the living
room floor and child's bedroom floor and bedding. Der p 1 levels were
analysed both as geometric mean microg/g of fine dust and as microg/m2.
Questionnaires collected information about factors which might influence
these levels, and an average relative humidity in the bed and on the bedroom
floor was also measured. RESULTS: Similar geometric mean levels of Der p 1
were found at each floor site - 25.5 microg/g (95% CI: 22.8-28.5) in the
living room and 26.4 microg/g (95% CI: 23.7-29.3) on the child's bedroom
floor. The geometric mean level of Der p 1 in the child's bed was 46.6
microg/g (95% CI: 42.3-51.3). After controlling for possible confounders,
geometric mean living room and bedroom floor Der p 1 levels were
significantly higher in households with older carpet than households with no
carpets or newer carpets, and higher in the autumn. Households with three or
more children had higher levels of Der p 1 than households with fewer
children. Bedding levels were significantly higher in beds with kapok or
inner sprung mattresses, or wool underlays and at relative humidities above
the mean (51%). CONCLUSION: The very high levels of house dust mite allergen
(Der p 1) found in Wellington are likely to be due to a variety of life-style
and climatic factors. However, the type and age of floor covering appears to
be the single most important factor.
<5>
AN 98005553
AU Kemp T. Pearce N. Fitzharris P. Crane J. Fergusson D. St. George I.
Wickens K. Beasley R.
IN Department of Medicine, Wellington School of Medicine, New Zealand.
TI Is infant immunization a risk factor for childhood asthma or allergy?.
SO Epidemiology. 8(6):678-80, 1997 Nov.
LM Not at Dartmouth/DHMClibraries;request on interlibrary loan.
AB The Christchurch Health and Development Study comprises 1,265 children born
in 1977. The 23 children who received no diphtheria/pertussis/tetanus (DPT)
and polio immunizations had no recorded asthma episodes or consultations for
asthma or other allergic illness before age 10 years; in the immunized
children, 23.1% had asthma episodes, 22.5% asthma consultations, and 30.0%
consultations for other allergic illness. Similar differences were observed
at ages 5 and 16 years. These findings do not appear to be due to
differential use of health services (although this possibility cannot be
excluded) or con-founding by ethnicity, socioeconomic status, parental atopy,
or parental smoking.
<6>
AN 97300802
AU Wickens K. Martin I. Pearce N. Fitzharris P. Kent R.
Holbrook N. Siebers R. Smith S. Trethowen H. Lewis S. Town I. Crane J.
IN Wellington Asthma Research Group, Wellington School of Medicine, New
Zealand.
TI House dust mite allergen levels in public places in New Zealand.
SO Journal of Allergy & Clinical Immunology. 99(5):587-93, 1997 May.
LM Dana. Incomplete holdings, check catalog.
AB BACKGROUND: House dust mite allergens are a risk factor for asthma in New
Zealand, and levels in domestic dwellings have been found to be high compared
with levels in most other countries. Studies in other countries have
demonstrated lower levels of Dermatophagoides pteronyssinus allergens in
public places compared with levels in domestic dwellings. OBJECTIVES: The
purpose of this study was to measure reservoir Der p 1 levels in public
places in New Zealand and to examine determinants of these levels. METHODS:
Reservoir dust was obtained in the two centers (Christchurch and Wellington)
from hotels, hospitals, rest homes, churches, primary schools, childcare
centers, cinemas, bank head offices, and airplanes; samples were also
obtained from ski lodges. Single measurements of temperature and relative
humidity were taken with thermohygrometers and an average humidity over 2
weeks was estimated with use of waxed wooden sticks. Information was
collected on building construction, type of heating, and frequency of
cleaning. Der p 1 levels (micrograms per gram of fine dust) for floor (n =
202), bed (n = 65), and seat (n = 24) samples in public places were expressed
as geometric means (95% confidence intervals). RESULTS: Der p 1 levels in
public places were significantly lower than domestic levels in both
Wellington and Christchurch. Both floor and bed levels were higher in hotels
than in other public places. After controlling for potential confounders,
floor Der p 1 levels were higher with carpeted floors (p < 0.0001) and lower
with recent cleaning (p = 0.02) and bed Der p 1 levels were higher with
timber wall construction (p = 0.03). Other building, heating, or cleaning
characteristics did not show significant association with allergen levels.
CONCLUSION: Der p 1 levels were much lower in public places than in domestic
dwellings with floor levels primarily affected by floor covering.