reference librarian comments, March 2000
| On Doctoring MEDLINE searches, with reference librarian comments, March 2000 |
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The question was
In children with familial history of Autism, is MMR vaccination associated with a higher likelihood of develeping autism. I also found an interesting web site on this issue with a critical response to the recent publication that dispels the link between MMR and autism (http://whale.to/Vaccines/autism_mmr_link.html). This is my second search, I hope you receive this one.
1 exp Vaccination/ results= 8628
2 exp Autistic disorder/ results= 2008
3 Measles vaccine/ or Mumps vaccine/ or Rubella vaccine/ results= 1589
4 1 and 3 results= 486
5 2 and 4 results= 2
6 1 and 2 results= 2
7 2 and 3 results= 29
8 limit 7 to ((newborn infant < birth to 1 month > or infant results= 25
< 1 to 23 months > or preschool child < 2 to 5 years > or child < 6 to 12 years >) and (afrikaans or albanian or arabic or armenian or azerbaijani or belorussian or bengali or bulgarian or burmese or catalan or chinese or croatian or czech or danish or dutch or english))
Reference Librarian comments
Interesting! I took a slightly different tack -- see below. I thought like this:
a) I'll make a set of references about the ETIOLOGY of autism. b) I'll make a huge set of all manner of MMR and any other vaccination term c) combine those two sets.
Medline 1991 to February 2000 # Search History Results
1 exp Autistic disorder/et [Etiology] 180
2 exp immunization programs/ or exp measles vaccine/ or exp mumps vaccine/ or exp rubella vaccine/ or exp vaccination/ or exp vaccines, combined/ or "mmr".mp. 11727
3 1 and 2 27
(the first ten of the 27 in set #3 are here below....)
<1> AN 99440258 AU Anonymous. TI MMR vaccine coverage shows signs of recovery. SO Communicable Disease Report. CDR Weekly. 9(39):345, 1999 Sep 24. LM Not at Dartmouth/DHMClibraries;request on interlibrary loan. <2> AN 99427486 AU Amin J. Wong M. IN National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Royal Alexandra Hospital for Children, Westmead, New South Wales. TI Measles-mumps-rubella immunisation, autism and inflammatory bowel disease: update. SO Communicable Diseases Intelligence. 23(8):222, 1999 Aug 5. LM Not at Dartmouth/DHMClibraries;request on interlibrary loan. <3> AN 99405850 AU Fombonne E. TI Are measles infections or measles immunizations linked to autism? [editorial]. SO Journal of Autism & Developmental Disorders. 29(4):349-50, 1999 Aug. LM Pre-1993 at Dana,1993-date at MFHSL. <4> AN 99418511 AU Roberts GT. TI MMR vaccination and autism [letter]. SO Lancet. 354(9182):951, 1999 Sep 11. LM Dana(complete) &MFHSL(1990-date);also Web,check catalog . <5> AN 99418510 AU Wakefield AJ. TI MMR vaccination and autism [letter]. SO Lancet. 354(9182):949-50, 1999 Sep 11. LM Dana(complete) &MFHSL(1990-date);also Web,check catalog . <6> AN 99301821 AU Bower H. TI New research demolishes link between MMR vaccine and autism [news]. SO BMJ. 318(7199):1643, 1999 Jun 19. LM Pre-1993 at Dana,1993-date at MFHSL. <7> AN 99303110 AU Taylor B. Miller E. Farrington CP. Petropoulos MC. Favot-Mayaud I. Li J. Waight PA. IN Department of Community Child Health, Royal Free and University College Medical School, University College London, UK. TI Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association [see comments]. CM Comment in: Lancet 1999 Jun 12;353(9169):1987-8 SO Lancet. 353(9169):2026-9, 1999 Jun 12. LM Dana(complete) &MFHSL(1990-date);also Web,check catalog . AB BACKGROUND: We undertook an epidemiological study to investigate whether measles, mumps, and rubella (MMR) vaccine may be causally associated with autism. METHODS: Children with autism born since 1979 were identified from special needs/disability registers and special schools in eight North Thames health districts, UK. Information from clinical records was linked to immunisation data held on the child health computing system. We looked for evidence of a change in trend in incidence or age at diagnosis associated with the introduction of MMR vaccination to the UK in 1988. Clustering of onsets within defined postvaccination periods was investigated by the case-series method. FINDINGS: We identified 498 cases of autism (261 of core autism, 166 of atypical autism, and 71 of Asperger's syndrome). In 293 cases the diagnosis could be confirmed by the criteria of the International Classification of Diseases, tenth revision (ICD10: 214 [82%] core autism, 52 [31%] atypical autism, 27 [38%] Asperger's syndrome). There was a steady increase in cases by year of birth with no sudden "step-up" or change in the trend line after the introduction of MMR vaccination. There was no difference in age at diagnosis between the cases vaccinated before or after 18 months of age and those never vaccinated. There was no temporal association between onset of autism within 1 or 2 years after vaccination with MMR (relative incidence compared with control period 0.94 [95% CI 0.60-1.47] and 1.09 [0.79-1.52]). Developmental regression was not clustered in the months after vaccination (relative incidence within 2 months and 4 months after MMR vaccination 0.92 [0.38-2.21] and 1.00 [0.52-1.95]). No significant temporal clustering for age at onset of parental concern was seen for cases of core autism or atypical autism with the exception of a single interval within 6 months of MMR vaccination. This appeared to be an artifact related to the difficulty of defining precisely the onset of symptoms in this disorder. INTERPRETATION: Our analyses do not support a causal association between MMR vaccine and autism. If such an association occurs, it is so rare that it could not be identified in this large regional sample. <8> AN 99303101 AU DeStefano F. Chen RT. IN Vaccine Safety and Development Branch, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. TI Negative association between MMR and autism [comment]. CM Comment on: Lancet 1999 Jun 12;353(9169):2026-9 SO Lancet. 353(9169):1987-8, 1999 Jun 12. LM Dana(complete) &MFHSL(1990-date);also Web,check catalog . <9> AN 99165071 AU Akobeng AK. Thomas AG. IN Department of Paediatric Gastroenterology, Booth Hall Children's Hospital, University of Manchester, Blackley, United Kingdom. TI Inflammatory bowel disease, autism, and the measles, mumps, and rubella vaccine. SO Journal of Pediatric Gastroenterology & Nutrition. 28(3):351-2, 1999 Mar. LM Dana. Incomplete holdings, check catalog. <10> AN 98288221 AU Roberts R. TI MMR vaccination and autism 1998. There is no causal link between MMR vaccine and autism [letter; comment]. CM Comment on: BMJ 1998 Mar 7;316(7133):715-6 SO BMJ. 316(7147):1824, 1998 Jun 13. LM Pre-1993 at Dana,1993-date at MFHSL.