On Doctoring MEDLINE searches, with reference librarian comments

The question was

"How valuable is PSA testing in male patients of 65
years and above?"

1 :  Prostate-specific antigen/du [Diagnostic Use]         {21}
2 :  limit 1 to yr=1990-1999         {21}
3 :  limit 2 to (evidence based medicine reviews and "aged < 65         {0}
and over >" and english)
4 :  limit 2 to ("aged < 65 and over >" and english and         {13}
yr=1990-1999)
5 :  limit 4 to topic reviews         {0}
6 :  limit 2 to topic reviews         {0}
7 :  exp Prostate-specific antigen/du [Diagnostic Use]         {21}
8 :  limit 4 to local holdings          { 10}

Reference Librarian comments

Great job. Congratulations. I played around with this search myself
and took a slightly different approach. I wish I had a little more
time to work with this one. I thought it turned out to be a little
tricky. AGE-GROUPS are sometimes a little difficult to tease out of
MEDLINE.

My playing-around went like this, and it is NOT necessarily "better"
than what you did.

1 : 
exp *Prostate-specific antigen/du [Diagnostic Use]
10

2 : 
exp *Prostate-specific antigen/
1892

3 : 
exp Mass screening/
20699

4 : 
exp *prostatic neoplasms/di
1358

5 : 
2 and 4
506

6 : 
limit 5 to ("aged < 65 and over >" or "aged, 80 and over")
281

7 : 
limit 6 to (human and english language)
217

8 : 
(sn or ep).fs.
243898

9 : 
3 or 8
257837

10 : 
7 and 9
49