On Doctoring MEDLINE searches, with reference librarian comments

The question was

"How does glucophage affect the metabolism of
Diabetes Type II patients?"

1 :  exp *Metformin/me,tu [Metabolism, Therapeutic Use]         {168}
2 :  exp *Diabetes mellitus, non-insulin-dependent/th [Therapy]         {427}
3 :  1 and 2         {3}
4 :  limit 3 to (local holdings and human and english language)         {2}
5 :  1         {168}
6 :  limit 5 to (local holdings and human and english language)         {97}
7 :  exp *Diabetes mellitus, non-insulin-dependent/th [Therapy]         {427}
8 :  1 and 6         {97}
9 :  6 and 7         {2}
10 :  from 9 keep 1-2         {2}
11 :  from 9 keep 1-2 2

Reference Librarian comments

Nice work. You obviously "get it." I have only one bit of advice.
"Therapy" as a subheading does not mean, nor does it include the
concept "Drug Therapy." Hence, I think set#2 is just not big
enough. I think you should have done this: exp *diabetes
mellitus, non-insulin-dependent/dt [Drug Therapy]

Just for fun, I did the search also. I used a few more subheadings
with set 1 and I decided to let set #2 get as big as possible (taking
ALL subheadings, not just Drug Therapy) -- and then I whittled it
down with various limits. Finally, I thought a REVIEW article would
be nice. Anyway, it's just another approach.

Here's the strategy I used, and the references gotten in the last set
I copied (in case you're interested) at the very bottom of this
message.

1 : 
exp *Metformin/me,ae,po,to,tu,ct [Metabolism, Adverse
Effects, Poisoning, Toxicity, Therapeutic Use,
Contraindications]
{226}

2 : 
exp *diabetes mellitus, non-insulin-dependent/
{9368}

3 : 
1 and 2
{132}

4 : 
limit 3 to (human and english language)
{113}

5 : 
limit 4 to review articles
{15}