On Doctoring MEDLINE searches, with reference librarian comments

The question was

"... a 17 yo female patient with primary amenorrhea
(i.e. never had a menstrual period). Dr. Edwards has detected no
pathology, but asked me simply to find out more about it such as
possible causes and side effects."

1 :  exp *Amenorrhea/co,pc,pp,di,dt,th [Complications,         {233}
Prevention & Control, Physiopathology, Diagnosis, Drug
Therapy, Therapy]
2 :  1 and primary.tw.         {33}
3 :  limit 2 to (human and english language and female and         {14}
adolescence < 13 to 18 years >)
4 :  from 3 keep 1-14          {14}

Reference Librarian comments

A fine job. Congratulations. I went into a trance to see if there
were maybe some other approach.

I supposed that maybe "amenorrhea" is stating something negatively.
(Something isn't flowing...) What if we just look at "Menarche" --
like this?

1 :  exp *Menarche/ph,de,px,eh,ge,me [Physiology, Drug Effects,
Psychology, Ethnology,
Genetics, Metabolism]
2 :  1 and (delay$ or absence).mp.

I got 14 references. Interesting factors: athletics, genetics,
stress, sleep, arthritis, etc.