On Doctoring MEDLINE searches, with reference librarian comments

The question was

"What birth control pills are most effective and
safest for an adolescent woman predisposed to or having cardiovasular
disease?"

I found limited information on this topic. Most reviews examined the
cardiovascular effects of birth control on adolescent women.

1 :  exp Contraceptives, oral/         {13481}
2 :  exp Cardiovascular diseases/         {306058}
3 :  1 and 2         {1355}
4 :  limit 3 to adolescence < 13 to 18 years >         {210}
5 :  Amino acid metabolism, inborn errors/ or Atherosclerosis/         {245102}
or Blood pressure/ or Cardiovascular diseases/ or
Cholesterol/ or Lipoproteins/ or Mutation/ or
Peptidyl-dipeptidase a/ or "Polymorphism (genetics)"/ or
Risk factors/ or "genetic cardiovascular disease".mp.
6 :  exp androgen antagonists/ or exp cardiovascular diseases/         {358082}
or exp contraceptives, oral/ or exp contraceptives, oral,
combined/ or exp estradiol/ or exp ethinyl estradiol/ or
exp gastrointestinal hemorrhage/ or exp gonadotropins/ or
exp menstrual cycle/ or "safe oral contraceptives".mp.
7 :  exp cardiomyopathy, hypertrophic/ or exp cardiovascular         {325504}
diseases/ or exp diabetes mellitus, non-insulin-dependent/
or exp hypertension/ or exp insulin resistance/ or exp
magnesium/ or exp myocardial ischemia/ or exp obesity in
diabetes/ or Magnesium deficiency/ or "predisposed
cardiovascular disease".mp.
8 :  6 and 7         {306267}
9 :  limit 8 to (human and english language and review articles         {793}
and female and adolescence < 13 to 18 years >)
10 :  exp cerebrovascular disorders/ or exp myocardial         {185459}
infarction/ or exp risk factors/ or "high risk".mp.
11 :  exp Contraceptives, oral/         {13481}
12 :  10 and 11         {1655}
13 :  limit 12 to (local holdings and human and english language         {23}
and review articles and female and adolescence < 13 to 18
years >)
14 :  from 13 keep 1,3-4,21          {4}

Reference Librarian comments

Wow! You had some Medline fun. You lost me after set #4, but it's
obvious that you're working away nicely on the system. I kinda wish
you had stuck with set #4, but I wasn't there following your
thinking, etc.

Just for fun, I played with the idea here (below). My set #4 is much
like yours, except that I "focused" the set #1 concept and I used
some subheadings. Then after set #4 I started doing various limits.
Those 13 that I got in set #6 I copied below at the very end of this
message.

1 : 
exp *Contraceptives, oral/ad,ae,im,me,pd,ct,tu [Administration &
Dosage, Adverse Effects,
Immunology, Metabolism, Pharmacology, Contraindications, Therapeutic Use]
5554

2  : 
exp cardiovascular diseases/
306058

3  : 
1 and 2
784

4 : 
limit 3 to adolescence < 13 to 18 years >
138

5 : 
limit 4 to (human and english language)
119

6 : 
limit 5 to review articles
13