Research Interests
Neurobiology
research interests on factors influencing the formation of connections between neurons and their target cells. Using regeneration of specific nerve-muscle connections in the crayfish abdominal muscles as a tool to study neuronal connectivity, a model system has been established that can be surgically manipulated by altering cell number and orientation prior to regeneration. As regeneration proceeds under different scenarios, information is obtained on synaptic plasticity, repression of synaptic potentials, competition between neurons for target cells and nerve-muscle trophic interactions.
Selected Publications
Regeneration studies on a crayfish neuromuscular system. I. Connectivity changes after intersegmental nerve transplants. [M.K. Worden, J.C. Hwang and S.J. Vélez (1988) J. Neurobiol. 19:127-140]
Regeneration studies on a crayfish neuromuscular system. II. Effect of changing the nerve entry point into the muscle field on the gradient of innervation. [L.G. Goransson, W.P. Hunt and S.J. Vélez (1988) J. Neurobiol. 19:141-152]
Regeneration of an identifiable motoneuron in the crayfish. I. Patterns of reconnection and synaptic strength established in normal and altered targe areas. [W.P. Hunt and S.J. Vélez (1989) J. Neurobiol. 20:703-717]
Regeneration of an identifiable motoneuron in the crayfish. II. Patterns of reconnection and synaptic strength established in the presence of an extra nerve. [W.P. Hunt and S.J. Vélez (1989) J. Neurobiol. 20:718-730]
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