BIOLOGY 43. Developmental Biology
10F: 9
An analysis of early cell and tissue development leading to organ differentiation. Fertilization, morphogenesis, and cell differentiation will be considered in terms of recent advances in developmental biology.
Prerequisite: Biology 15. Dist: SCI. Erives.
BIOLOGY 47. Human genomics
11W: 2
This course is an introduction to genomics, the study of biological organisms from a whole-genome perspective, and focuses on the genome of Homo sapiens and its relations to other genomes. Some of the topics discussed include: the sequencing, assembly and annotation of the human genome; the human gene complement; evolution of vertebrate and human genomes; comparative primate genomics; human nucleotide diversity and the human haplotype map; drug discovery in the post-genomic era; and a variety of experimental whole genome approaches for identifying global changes in gene regulation (e.g. subtractive hybridization, micro-array analysis, serial analysis of gene expression and whole-genome bioinformatics).
Prerequisites: Biology 13 or 15. Dist: SCI. Erives.
BIOLOGY 75 / BIOLOGY 175. Genomic Circuitry
10S: 10
Many genomes, including the human genome, have been sequenced. Now, increasing attention has turned to a fundamental component of these genomes: gene circuitry, i.e. the “wiring” that links together activated genes in a genomic program. Specialized DNA sequences determine where and when a given gene is expressed during an organism’s life cycle. These genomic “regulatory” sequences also play a major role in basic evolutionary processes. How do regulatory sequences encode differential gene expression? How do they evolve? How do we identify and understand their logic? This course will investigate these questions as well as landmark papers necessary to understand present and future work in this field.
Prerequisite: Biology 23, 24 or 27. Dist: SCI. Erives
BIOLOGY 262. Mechanisms in Evolution and Development
09F, 10W, 10S, 11F
Graduate student (MCB or EEB) primary literature reading course. Offered Fall, Winter, Spring terms for credit. Group meets voluntarily during Summer term.
(NOTE to MCB/EEB students: I'll be teaching Bio262 Fall '09 and Spring '10 terms at Centerra, while Kevin Peterson will be teaching this in Winter '10 term at Gilman Hall.)