"...the genome is... a mosaic of independent molecular blue-prints for the building of individual
cellular constituents. In the execution of these plans,... co-ordination
is... of absolute survival value... the genome contains not only a series of blue-prints, but a
co-ordinated program of protein synthesis and the means of controlling its
—F. Jacob and J. Monod, J. Mol. Biol. (1961)
Our research team is making use of whole-genome sequences from a variety of
organisms to explore how life works and how it evolves. Our research team has
made advances in several areas from animal development and evolution to
evolution of the genetic code itself.
On an important mechanism in animal development and its evolution over the past 40 million years (My):
Identified and decoded a developmental morphogen gradient encoding scheme in a genome and
its mode of evolution.
On the evolutionary origins of animals (~1,000 Mya):
Identified and documented the evolutionary origin of the Myc signaling pathway as
having occurred in the stem-Holozoan ancestor.
Read more here:
On the origins of life (>4,000 Mya):
Identified the evolutionary origin of the amino acid codon table and
L-amino acid and D-ribose homochiralities.
Read more here:
The DNA sequence above is a short snippet from the human genome.
Click through our lab web pages to find out what it is!
"However clever you think cells are: [remember] they are clever!"
40th anniversary of the
Positional Information model of morphogen gradients.
Developmental Biology GRC
Andover, New Hampshire