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Natural killer cells are
innate effector cells serving as a first line of
defense against certain viral infections and tumors. Natural
killer cells have the ability to recognize and kill a variety of different
tumor types using specific cell surface receptors to recognize tumors. These
activating NK cell receptors that recognize tumor cells have been identified
in mice and humans natural killer cells. Dartmouth researchers have now
found that a chimeric NK receptor molecule composed
of a natural killer cell receptor (e.g., a C-type lectin-like
NK cell receptor) and an immune signaling receptor (e.g., a CD3-zeta
or Fc epsilon receptor-gamma chain) expressed on
the surface of a T cell can facilitate killing of a tumor cell and production
of proinflammatory cytokines. The chimeric receptor molecules provide a means for the
patient’s own immune cells to recognize and activate anti-tumor
immunity and establish long-term, specific, anti-tumor responses.
Accordingly, the chimeric receptor molecules are
useful for treating tumors or preventing growth of dormant or residual tumor
cells. The initial findings have been published in the journal Blood
(Zhang et al. 106:1544 (2005)). This technology is claimed in
the published Patent Corporation Treaty Application No. PCT/US2005/031100. We
are seeking an industrial partner interested in its commercialization. (Ref:
J267) |
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«Technology Transfer Office : Sponsored Projects : Dartmouth College |
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11 Rope Ferry Road #6210 |
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Hanover, NH 03755-1404 |
Phone: (603) 646-3027 |
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Fax: (603) 646-3670 |
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