Professor of Physiology
Dr. Guyre received his B.A. (Biology) from Montclair State University in 1972 and his M.S. (Microbial Genetics;1976) and Ph.D. (Microbiology/Immunology;1979) from the University of New Hampshire. After a postdoctoral fellowship with Dr. Allan Munck in the Physiology Department, he joined the faculty in1981. He is currently Professor of Physiology, a member of the Norris Cotton Cancer Center, and Co-Director of the Herbert C. Englert Cell Analysis Laboratory.
Dr. Guyre's principal research interest is understanding how hormones and cytokines regulate the functional activity of white blood cells including monocytes, dendritic cells, lymphocytes, and neutrophils. The goal of Dr. Guyre's current research is to elucidate the physiologic interactions between steroid hormones that often regulate immune responses and molecules that activate the immune system such as cytokines and interferons. For example, bacterial infections stimulate the production of cytokines that activate leukocytes, but also feed back via the brain and pituitary to stimulate the release of cortisol from the adrenal gland. Cortisol (as well as related steroids that are used therapeutically as anti-inflammatory agents) then interacts with cytokines to either enhance or inhibit leukocyte activation as needed. Together with collaborators Drs. Wira, Yeager, Morganelli and Fanger, Dr. Guyre's research team is identifying the mechanisms by which leukocyte receptors and signaling pathways are regulated by hormones and cytokines to enhance the killing of pathogens and/or suppress inflammation in sepsis, autoimmunity and cardiovascular disease.
Wallace, P.K., Keler, T., Coleman, K., Fisher, J., Graziano, R.F.,Guyre, P.M. and Fanger, M.W. Humanized mAb22 binds the human high affinity Fc receptor for IgG (FcgRI), blocks phagocytosis and modulates receptor expression. J. Leuk.Biol. 62:469-479, 1997.
Keler T, Guyre PM, Vitale LA, Sundarapandiyan K, van DeWinkel JG, Deo YM, Graziano RF. Targeting weak antigens toCD64 elicits potent humoral responses in human CD64transgenic mice. J Immunol. 165:6738-42, 2000.
Sulahian, T.H., Högger, P., Wardwell, K., Goulding, N.J., Sorg,C., and Paul M. Guyre. Human monocytes express CD163,which is upregulated by IL-10 and identical to p155. Cytokine12:1312-1321, 2000.
Sulahian, T., K. Hintz, K. Wardwell, and P. Guyre.Development of an ELISA to measure soluble CD163 in biological fluids. J Immunol Methods, 252:25-31, 2001.
Wallace PK, Tsang KY, Goldstein J, Correale P, Jarry TM, Schlom J, Guyre PM, Ernstoff MS, Fanger MW. Exogenous antigen targeted to FcgammaRI on myeloid cells is presented in association with MHC class I. J Immunol Methods.48:183-94, 2001.
Vailes LD, Sun AW, Ichikawa K, Wu Z, Sulahian TH, Chapman MD, Guyre PM. High-level expression of immunoreactive recombinant cat allergen (Fel d 1): Targeting to antigen-presenting cells. J Allergy Clin Immunol. 110:757-62, 2002.
Hintz KA, Rassias AJ, Wardwell K, Moss ML, Morganelli PM, Pioli PA, Givan AL, Wallace PK, Yeager MP, Guyre PM. Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. J Leukoc Biol. 72:711-7, 2002.
Fillinger MP, Rassias AJ, Guyre PM, Sanders JH, Beach M, Pahl J, Watson RB, Whalen PK, Yeo KT, Yeager MP. Glucocorticoid effects on the inflammatory and clinical responses to cardiac surgery. J Cardiothorac Vasc Anesth. 16:163-9, 2002
Goldstein JI, Goldstein KA, Wardwell K, Fahrner SL, Goonan KE, Cheney MD, Yeager MP, Guyre PM. Increase in plasma and surface CD163 levels in patients undergoing coronary artery bypass graft surgery.
Atherosclerosis 170:325-32, 2003.Yeager MP, Rassias AJ, Fillinger MP, Discipio AW, Gloor KE, Gregory JA, Guyre PM. Cortisol antiinflammatory effects are maximal at postoperative plasma. Crit Care Med. 2005 Jul;33(7):1507-12.
Pioli PA, Weaver LK, Schaefer TM, Wright JA, Wira CR, Guyre PM. Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages. J. Immunol. 2006 Jun 1;176(11):6647-55.
Weaver LK, Hintz-Goldstein KA, Pioli PA, Wardwell K, Qureshi N, Vogel SN, Pivotal advance: activation of cell surface Toll-like receptors causes shedding. J Leukoc Biol. 2006 Jul;80(1):26-35.
Weaver LK, Pioli PA, Wardwell K, Vogel SN, Guyre PM Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like. J Leukoc Biol. 2007
Mar;81(3):663-71.Pioli PA, Jensen AL, Weaver LK, Amiel E, Shen Z, Shen L, Wira CR, Guyre PM.
Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8
production. J Immunol. 2007 Nov 1;179(9):6284-90.Yeager MP, Pioli PA, Wardwell K, Beach ML, Martel P, Rassias AJ, Guyre PM.
(2008). In vivo exposure to high or low cortisol has bi-phasic effects on
inflammatory response pathways of human monocytes. Anesth Analg (In Press).
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