Assistant Professor of Medicine and Physiology
Dr. de Muinck received his M.D. degree from the University of Groningen, The Netherlands, in 1983 and then earned his Ph.D from the same university in the field of Cardiology in 1994. After serving on the faculties of the Cardiovascular Research Institute at Maastricht and in the Interventional Cardiology Department at the University Hospital at Groningen, he came to the Dartmouth Hitchcock Medical Center in the Department of Medicine and joined the Physiology Department at Dartmouth Medical School in 2002. He jointly serves as a cardiologist at DHMC and maintains an active and productive research laboratory in the Department of Physiology.
Dr. de Muinck is interested in:
- therapeutic neovascularization, both angiogenesis and arteriogenesis;
- homing of synthetic peptide sequences to endothelial cell surface molecules that are preferentially expressed on angiogenic endothelium, both for therapeutic and imaging purposes;
- molecular imaging of angiogenic and arteriogenic vessels;
- interventional cardiology and specifically the prevention and treatment of in-stent restenosis;
- cardiovascular physiology;
- translation of experimental data in the field of neo-vascularization to cardiac patient care.His laboratory funtions as a core for cardiovascular phenotyping of genetically altered mouse models, using sophisticated structure function analysis including pressure volume measurements, echocardiography, laser doppler flow and MR flow measurements, 3 dimensional reconstrcution of CT angiographic images of the vascular tree and 3 dimensional reconstruction of the histologic sections.
His research applies to patient care as well as experimental settings in large and small animal models.
Zhen W. Zhuang, Ling Gao, Masahiro Murakami, Justin D Pearlman, Terry J Sackett, Michael Simons, Ebo D. de Muinck. Multidetector row computed tomographic angiography with three-dimensional volume rendering in rodents: non-invasive quantification of arteriogenesis. Radiology 2006; 240:698-707.
Baklanov DV, Moodie KM, McCarthy FE, Mandrusov E, Chiu J, Aswonge G, Cheng J, Chow M, Simons M, de Muinck ED. Comparison of transendocardial and retrograde coronary venous intramyocardial catheter delivery systems in healthy and infarcted pigs. Cath Cardiovasc Interv 2006: 68:416-423.
Mandinov L, Moodie KL, Mandinova A, Zhuang Z, Redican F, Baklanov D, Lindner V, Maciag T, Simons M, de Muinck ED. Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries. Am J Physiol: Heart and Circulatory Physiology 2006;291:H2692-H2697.
Buehler A, van Zandvoort, MAJM, Stelt BJ, Hackeng TM, Schrans-Stassen BHGJ, Bennaghmouch A, Hofstra L, Cleutjens JPM, Duijvestijn A, Smeets MB, de Kleijn DPV, Post MJ, de Muinck ED. c-NGR, a novel homing sequence for targeted molecular imaging of murine cardiac angiogenesis in vivo. Arteriosclerosis Thrombosis and Vascular Biology 2006;26:2681-2687.
de Muinck ED, Nagy N, Tirziu D, Murakami M, Gurusamy N, Goswamy SK, Ghatpande S, Engelman RN, Das DK, Simons M. Protection Against Myocardial Ischemia–Reperfusion Injury by the Angiogenic Masterswitch Protein PR 39 Gene Therapy: The Roles of HIF1α Stabilization and FGFR1 Signaling. Antioxidants & Redox Signaling 2007;9:437-445.
de Muinck ED. Gene and cell therapy for heart failure. Antioxidants & Redox Signaling 2008: in press.
[8/28/08]