Professor of Physiology and Adjunct Professor of Biomedical Engineering
Dr. Daubenspeck received his B.S.M.E. from Swarthmore College in 1966, and his Ph.D. in Engineering Science from Dartmouth College in 1972. After postdoctoral work as an NIH research fellow and research associate in Biomedical Engineering at the University of Southern California with Professor Fred S. Grodins, Dr. Daubenspeck joined the faculty of the Department of Physiology at Dartmouth Medical School in 1974.
Dr. Daubenspeck had a long interest in the neural processes involved in regulation of the respiratory pattern of humans with respect to the influence of the mechanics of the respiratory system and in the role of upper airway mechanoreceptors that provide feedback to control upper airway muscles, holding the compliant airway open against the collapsing tendency of the negative pressures required for inspiratory flow.
He has used evoked potentials stimulated by oral pressure pulses to characterize the role of respiratory mechanoreceptors in the control of breathing and has examined their role in pathological conditions that affect respiratory pattern regulation and the perception of respiratory discomfort in patients.
Recently, Dr. Daubenspeck's research interests have turned to the evaluation of cardiorespiratory control as indicated by the nature of the beat-to-beat variability in the cardiac rhythm. Since regulation of the heart rate involves a host of important regulation pathways in the central nervous system, abnormalities in those control mechanisms will be reflected in changes in the character of heart rate variability. This approach is being applied to data obtained from neonatal human infants, and from mice and piglets that represent possible models of Sudden Infant Death Syndrome (SIDS). Extension of this sort of analysis to respiration has led to an interest in new ways of measuring breathing in neonatal mice and rats including acoustic plethysmography.
Daubenspeck, J.A., L. M. Lim, and M. Akay. Global field power helps to separate respiratory-related evoked potentials from electromyographic contamination. J. Appl. Physiol. 88:282-290, 2000.
Daubenspeck, J.A., H.L. Manning and M. Akay. Contribution of supraglottal mechanoreceptor afferents to respiratory-related evoked potentials in humans. J. Appl. Physiol. 88:291-299, 2000.
Akay, M. and J. A. Daubenspeck. Respiratory related evoked responses to graduated pressure pulses using wavelet transform methods. Ann. Biomed. Engg. 28: 1126-35, 2000.
Akay, M. and J. A. Daubenspeck. Effect of supraglottic mechanoreceptors on spatial mapping of respiratory related evoked responses using wavelet and Laplacian methods. Ann. Biomed. Engg. 28: 1270-1380, 2000.
Simon, P.M., A.M. Habel, J.A. Daubenspeck, and J.C. Leiter. Vagal feedback in the entrainment of respiration to mechanical ventilation in sleeping humans. J. Appl. Physiol. 89: 760-769, 2000.
BuSha, B.F., B.G. Judd, H.L. Manning, P.M. Simon, B.C. Searle, J.A. Daubenspeck, and J.C. Leiter. Identification of respiratory vagal feedback in awake normal subjects using pseudo-random unloading. J. Appl. Physiol. 90: 2330-2340, 2001.
Daubenspeck, J.A., H.L. Manning and J.C. Baird. Midlatency respiratory-related somatosensory activity and perception of oral pressure pulses in normal humans. J. Appl. Physiol. 90: 2048-2056, 2001.
Akay, M., J.C. Leiter, and J.A. Daubenspeck. Reduced respiratory-related evoked activity in subjects with obstructive sleep apnea syndrome. J. Appl. Physiol. 94(2): 429-438, 2003.Chernov, M.M, J.A. Daubenspeck, J.S. Denton, J.R. Pfeiffer, R.W.Putnam, and J.C. Leiter. A computational analysis of central CO2 sensitivity in Helix aspersa. Am. J. Physiology, Cell Physiol. 292(1):C278-91, 2007.
Daubenspeck JA. Li A. Nattie EE. Acoustic plethysmography measures breathing in unrestrained neonatal mice. J. Appl. Physiol. 104(1):262-8, 2008.
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