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Localization of the Cystic Fibrosis Transmembrane Conductance Regulator |
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Project 3: Structural Analysis of Protein-Protein
Interactions that Modulate the
Function and Intracellular Localization of the Cystic Fibrosis
Transmembrane Conductance Regulator
 |
Dr.
Dean Madden is an Associate Professor in the Department
of Biochemistry.
The long-term interest of Dr.
Madden’s laboratory is to understand the structural basis of
ion channel function. He is particularly interested in understanding how
two PDZ proteins, EBP50 and CAL, interact with and regulate CFTR function
and plasma membrane expression. The goal of Dr. Madden’s COBRE proposal
is to understand how the formation of CFTR:PDZ protein complexes and the
biochemical and stereochemical parameters that govern these interactions
control both the localization and oligomeric state of the CFTR Cl channel.
To these ends he will utilize a combination of X-ray crystallographic
and proteomic approaches. Thus, he will also be a major user of the Proteomics
Core. Dr. Madden will interact with Dr. Swiatecka-Urban (Project
2), and Dr. O’Toole (Project 1).
Bruce
Stanton, Ph.D., is Dr. Madden's mentor.
