Curriculum Vitae
JAY CLARK DUNLAP
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Curriculum Vitae
JAY CLARK DUNLAP |
Curriculum Vitae
JAY CLARK DUNLAP
PERSONAL
Born May 9, 1952 Ludlow, MA
Address: Department of Genetics, Dartmouth Medical School, Hanover, NH 03755-3844
Phone: (603) 650-1108 email: jay.c.dunlap@dartmouth.edu
Position: Chairman, Department of Genetics, Professor of Biochemistry
Affiliations: Core Member, Molecular Genetics Center
Molecular and Cellular Biology Graduate Program
Chairman, Genetics Graduate Program
EDUCATION
University of California, Santa Cruz, CA. Postdoctoral Research in Genetics, Molecular Genetics, 1980-1984.
Harvard University, Cambridge, MA. PhD in Biology, 1979.
Harvard University, Cambridge, MA. AM in Biology, 1975.
University of Washington, Seattle. BS in Oceanography with College Honors, Magna cum Laude, 1974.
University of Washington, Seattle. BS in Chemistry with College Honors, Magna cum Laude, 1974.
PREVIOUS EMPLOYMENT AND PROFESSIONAL EXPERIENCE
Chair, Department of Genetics, November 1999
Professor of Biochemistry, July 1994
Associate Professor of Biochemistry, 1990
Assistant Professor of Biochemistry and Core Member of the Molecular Genetics Laboratory, 1987
National Institutes of Health Postdoctoral Fellow, Dept. Biology, University of California, Santa Cruz, CA. 1983-1984.
Damon Runyon - Walter Winchell Memorial Fellow in Cancer Research, Dept. Biology, University of California, Santa Cruz, CA. 1980-1983.
Laboratory Coordinator, Phytoplankton Ecology Course, Friday Harbor Laboratories of the University of Washington, San Juan Island, WA. 1978
Teaching Fellow in Biology, Harvard University, Cambridge, 1974-1979. Introductory Biology (1974-1976), Cell Biochemistry and Physiology (1975), Biological Oceanography (1976-1978), Independent Tutorial (full year mini-course) on Biological Clocks (1979-1980), Resident Tutor in Biology, Dunster House (1977-1980).
Workshop on Biological Clocks, Hopkins Marine Station, Pacific Grove, CA. 1977.
Marine Botany Course, Marine Biological Laboratory, Woods Hole. 1975.
Physiology Course, Marine Biological Laboratory, Woods Hole. 1974.
Project Director/Principal Investigator, NSF Student Originated Studies Grant GY-10751, University of Washington, Seattle. 1972-1974.
Tutor in Science and Mathematics, Minority Affairs Office, University of Washington, Seattle. 1972-1974.
SCHOLARSHIPS AND FELLOWSHIPS
National Institutes of Health Postdoctoral Fellowship in Genetics, 1983-1984.
Damon Runyon - Walter Winchell Memorial Fellow in Cancer Research, 1980-1983.
National Institutes of Health Predoctoral Traineeship, 1974-1979.
Tuition Award, NSF Workshop on Biological Clocks, 1977.
Tuition Award, Marine Biological Laboratory, Woods Hole, 1975.
ACADEMIC HONORS AND AWARDS
2005 (first) recipient of Robert L. Metzenberg Award for contributions to Neurospora genetics
1998 - MERIT Award, NIGMS
1998 - Visiting Professor, University of Rome
1992 - 1997 Senior Scientist Award, National Institute of Mental Health
1991 Honma International Prize For Biological Rhythms Research - a prize of ¥1,000,000, awarded no more frequently than every other year to an investigator of any nationality under 40 who has made "exceptional contributions in the field of circadian rhythms" (previously awarded in 1988, 1986, 1984). The 1991 award was the first given for work in genetics and molecular biology.
Damon Runyon - Walter Winchell Fellowship in Cancer Research, 1980.
Phi Beta Kappa, 1974.
Phi Lambda Upsilon (National Chemistry Honorary), 1974.
Graduation with degrees in Oceanography and Chemistry, Magna cum Laude in each, 1974.
NATIONAL and PROFESSIONAL SERVICE
National Institutes of Health
Microbial Genetics and Physiology Study Section, 1993
Trans-NIH Workshop to coordinate research by the National Center for Sleep Disorders Research (1995)
Special Study Section for Circadian Rhythms, 1997, 00, 01
Site Visit, evaluating Circadian Rhythms Program Project, Brandeis Univ. 1997
Ad Hoc reviewer of proposals for Genetics Study Section, Microbial Genetics and Physiology Study Section
Board of Scientific Advisors, Laboratory of Molecular and Cellular Regulation, NIMH Intramural Program, 1999
National Advisory Council, National Institute of General Medical Sciences, National Institutes of Health, Bethesda 1999 - 2003
National Science Foundation
Regular Member - NSF Grant Review Panel on Microbial Genetics (1989 - 1992)
Ad Hoc reviewer for Eukaryotic Genetics Panel, Metabolic Biology Panel, Biochemical Genetics
US Department of Agriculture
Ad Hoc reviewer of proposals
Air Force Office of Scientific Research
Ad Hoc reviewer of proposals
National Academy of Sciences:
1984 Workshop on Nonmammalian Models for the Study of Biological Regulation
1989 One of 5 member Advisory Panel for documentary entitled "Chronobiology", a part of the series called The Infinite Voyage co-produced by WQED (Pittsburgh) and the NAS under the auspices of the National Academy of Sciences Film Committee
NSF Center for Biological Timing - External Advisory Committee, 1991 - 2002
UK Medical Research Council, outside reviewer for the Laboratory of Molecular Biology, Neurobiology Division, Cambridge. 2004
External Advisory Committee, UO1 (Glue Grant) GM61388 "Pharmacogenetics of Phase II Drug Metabolizing Enzymes, Mayo Clinic
COMMITTEE RESPONSIBILITIES - Institutional (dates of overlapping calendar years)
Molecular Genetics Center - 1984 to 1992; member of the original committee charged with developing and implementing a laboratory and "center" for Molecular Genetics at Dartmouth. Since this beginning, I have been involved in numerous formal and informal committees concerned with the acquisition of funds and equipment, and the development and implementation of a coherent curriculum in Molecular Genetics. Biochemistry 61 (see above) was the first course specifically developed and implemented as a part of this ongoing effort.
Graduate Committee of the Biochemistry Program - 1985 to 1988, Chairman from 1986 to 1988
Institutional Biohazard Committee - NIH mandated oversight committee and clearing house for institutional use of recombinant DNA technologies - Chairman from 1985 to 1989
Committee to Design the Research Labs at the new Dartmouth Hitchcock Medical Center complex - 1986 to 1988
Dean's Committee for developing the Dartmouth Plan for Extended Guarantee of Compensation (PEGC) - 1987 to 1989 and 1991, plan approved by the Trustees of Dartmouth College in June 1989
Proposal Review Committee of the Hitchcock Foundation - 1988 - 1995
Dean's Committee to Develop an Institutional Policy regarding Maternity Benefits 1989-1990
Interim Head of the Molecular Genetics Program of the Norris Cotton Cancer Center, 1989. Salary support normally provided by the Cancer Center during this period was donated to support incoming junior faculty in the Cancer Center and the Department of Biochemistry.
Thayer School of Engineering Internal Review Committee-1990
Norris Cotton Cancer Center Research and Education Committee - 1990 - Present
Norris Cotton Cancer Center Seminar Committee - 1992 - 1995
Genetics Vertical Working Group, 1994 – 1995
Center for Biological and Biomedical Computing - Operating Committee - 1995 – present
DNA Sequencing and Protein Chemistry Core Facility - oversight Committee - 1995 - present
MD/Ph.D Admissions Committee, 1996 - 1997
Search Committees:
Biochemistry/Molecular Genetics - 1986, 1987, 1988
Biochemistry/Neuroscience - 1985, 1986, 1987, 1988
Departmental Liaison on Biochemistry Chairman Search Committee - 1989, 1990, 1991, 1992
Biochemistry - 1994
Genetics/Markey -1994, 1996, 1998
Cancer Center 2001, 2002, 2003
Genetics – 1999, 2001, 2002, 2003
Dartmouth Medical School Deans' Advisory Board, 1999 - present
DMS Space Allocation Committee, 2001 - present
Thesis committees, Department of Biochemistry: 30 students to date, names available
EDITORIAL ACTIVITIES
Editor-in-Chief - Advances in Genetics, Academic Press, 1992 - Present
Editor Eukaryotic Cell (ASM Press) 2001 - 2006
Editorial Advisory Boards - Dartmouth Medicine, 1993 - 1999
Journal of Biological Rhythms, 1994 - 2002
Journals
Ad Hoc reviewer for Science, Nature, Cell, Neuron, Genetics, Journal of Biological Chemistry, Proceedings of the National Academy of Sciences (USA), EMBO Journal, Journal of Molecular Biology, Molecular and Cellular Biology, Archives of Biochemistry and Biophysics, Journal of Biological Rhythms, Molecular Microbiology, Journal of Neuroscience, Journal of Insect Biology
OFFICES AND COMMITTEE ASSIGNMENTS - professional societies
President, Society for Research on Biological Rhythms (500+ members) -1998 - 2000
President-Elect, Society for Research on Biological Rhythms -1996 - 1998
Elected Treasurer, Society for Research on Biological Rhythms -1992 - 1994
Committee to Sequence the Neurospora Genome - Chair, 1996 -1999
Committee to Order the Neurospora Genome - Chair, 1993 - 1995
Neurospora Policy Committee - Chair, 1993 - 1995
Fungal Genetics Policy Committee (oversight board for the National Fungal Genetics Stock Center, the Fungal Genetics Newsletter, and the biennial Fungal Genetics Conference); began service in 1989
INVITED LECTURES AND PRESENTATIONS
2006 – invited Plenary Lecture Neurospora 2006
2005 – Plenary lecture, Mexican Conference on Cellular and Molecular Biology
2005 – Guidant corporation
2005 – Univ. California San Francisco
2005 – Univ. Connecticut
2004 Cellular and Molecular Mycology Gordon Conference
2004 Univ. California Los Angeles
2004 Keynote speaker, Chronobiology Futures Meeting, Tokyo
2004 Univ. California Riverside
2004 Neurospora 2004
2003 National Academy of Sciences "Future Initiatives" meeting, Irvine
2003 Keynote Address, SUNY upstate graduate programs retreat
2003 University of Vermont
2003 Division of Sleep Medicine, Brigham and Women's Hospital, Boston
2003 Workshop on Photobiology, Fungal Genetics meeting, Asilomar
2003 Harvard College
2003– ITP Workshop on Mathematical Modeling
2003 – Chronobiology Gordon Conference, Italy
2003 British Society for Microbiology (declined due to conflict)
2003 – World Congress on Chronobiology (declined due to conflict)
2002 – Harvard Medical School
2002 – CIBA Foundation meeting on Clocks
2002 – Univ. Arizona
2002 – SRBR Meeting Symposium lecture
2002 – invited lecture – Neurospora 2002
2002 – Kobe University
2001 - Keystone Symposium on Circadian Clocks
2001 – Lunenberg Institute, Univ. Toronto
2001 – Univ. Tennessee
2001 – CIBA Foundation /Novartis Institute
2001 – Gordon Conference on Chronobiology
2000 - Institute for Biomolecular Science
2000 - UCSF
2000 - Medical Research Council Lecturer, Cambridge University, Cambridge, UK
2000 - Neurospora 2000
2000 - Society for Research on Biological Rhythms, Plenary Lecture
2000 - MD Anderson, Department of Molecular Biology, Houston, TX
2000 - PAS Domains in Biology, Invited lecturer, Research Triangle, NC
2000 - Cellular and Molecular Mycology Gordon Conference, session chair
2000 - 3éme Cycle Romand en Sciences biologiques, Villars-sur-Ollon, Switzerland
1999 - Juan March Symposium on Molecular Clocks, Madrid Spain
1999 - Plenary Lecturer, American Society Human Genetics Annual Meeting, San Francisco, CA
1999 - Fondation de Treilles, Provence, France
1999 - Chronobiology Gordon Conference, Barga Italy
1999 - University of Connecticut
1999 - Developmental Biology Gordon Conference, Andover, NH
1999 - University of Virginia
1999 - Davis Memorial Lecturer, University of Kansas, Lawrence, KS
1999 - Colorado State, Fort Collins, CO
1999 - Plenary Lecturer, Fungal Genetics Conference, Asilomar, CA
1999 - Special Lecturer, Franklin and Marshall College, Lancaster, PA
1998 - Juan March Symposium, Madrid Spain
1998 - Frontiers in Biochemistry, Biochemistry Graduate Students, Stanford University
1998 - Dept. Cellular and Developmental Biology, Harvard Univ.
1998 - Dept. Neurosciences, Tufts University
1998 - Society for Research on Biological Rhythms
1998 - Society for General Microbiology, Nottingham, UK Plenary Lecture, Main Symposium
1998 - Keynote Speaker, Neurospora Conference
1998 - Dept Biochemistry, Baylor University
1998 - Dept. Biochemistry, UMDNJ
1998 - Kobe Univ., Okayama Univ., Nagoya Univ., Yamaguchi Univ., Nara College
1998 - Japanese Society for Chronobiology - Invited Plenary lecture
1997 - Fungal Genetics Meeting, Asilomar, CA
1997 - Department of Molecular Biology, University of Alberta, Edmonton
1997 - Gordon Research Conference - Chronobiology, Session Chair and Speaker
1997 - Symposium "Gene Function to Cell Differentiation, National Inst. of Genetics, Tokyo
1997 - European Society for Chronobiology, Paris
1997 - Program in Genetics, Duke Univ.
1997 - Dept. Biological Sciences, Univ. Illinois
1996 - Department of Microbiology, New Jersey School of Medicine and Dentistry, Newark, NJ
1996 - Department of Genetics, University of North Carolina at Chapel Hill
1996 -Wadsworth Laboratories, New York State Department of Health, Albany, NY
1996 - Society for Research on Biological Rhythms
1996 - Sensory Transduction in Microorganisms Gordon Conference, Ventura, CA
1996 - Cellular and Molecular Mycology Gordon Conference, Holderness, NH
1996 - Department of Physiological Medicine, Ludwig-Maximilians-University, Munich, FRG
1995 - Department of Biology, Yale University, New Haven , CT
1995 - National Center on Sleep Disorders Research Workshop - Bethesda
1995 - World Conference on Chronobiology, Ferrara Italy (declined)
1995 - World Federation of Sleep Research Societies, Nassau, Bahamas (declined)
1995 - 19th International Summer School for Brain Research, Amsterdam
1995 - American Physiological Society Conference on Circadian Rhythms and Biological Clocks
1995 - Department of Biochemistry, Ohio State University, Columbus, Ohio
1994 Circadian Rhythms Symposium, Franklin and Marshal College, Lancaster, PA
1994 US/Japan Conference on Circadian Rhythmicity, Hawaii
1994 NSF/CBT Workshop on Circadian Rhythms of Drosophila and Related Insects, Charlottesville, VA
1994 Departments of Genetics and Biochemistry, University of Washington, Seattle, WA
1994 Institute of Molecular Biology, University of Oregon, Eugene, OR
1993 Ciba Foundation Symposium, "Circadian Clocks and Their Adjustment", London, England
1993 Department of Biology, Texas A&M, College Station, TX
1993 Gordon Conference on Chronobiology
1993 Department of Biology, University of Maine, Orono, ME
1992 Yamaguchi International Symposium on Circadian Rhythmicity, Yamaguchi, Japan
1992 FESN Workshop on Circadian Rhythms, New York City
1992 Society for Photochemistry and Photobiology, Florida
1992 EMBO Workshop on Molecular Biology of Circadian Rhythms, Leicester England
1992 Department of Biology, Stanford University, Stanford, CA
1992 Department of Biology, University of Massachusetts, Amherst, MA
1992 Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia
1992 First Center for Biological Timing Symposium, Charlottesville, VA
1992 Department of Biology, Northeastern University, Boston, MA
1991 Fourth Sapporo Symposium on Biological Rhythms, Sapporo Japan
1991 EMBO Symposium on Fungal Genetics, Berlin Germany
1991 Gordon Conference on Chronobiology, Irsee Germany
1991 Genetics Society of Canada, Kingston, Ontario
1991 FESN Study Group on Circadian Rhythms, Geneva, Switzerland
1991 Twentieth International Conference on Chronobiology, Tel Aviv, Israel
1991 Department of Neurobiology, Northwestern University, Evanston, IL
1990 California Institute of Technology, Division of Biology, Pasadena, CA
1990 Society for Research on Biological Rhythms, Jacksonville, FL
1990 Fungal Genetics Gordon Conference, Andover, NH
1990 Department of Microbiology, University of Kansas Medical Center, Kansas City, KS
1990 Wadsworth Labs, New York State Department of Health, Albany, NY
1990 Department of Microbiology, University of Vermont, Burlington, VT
1990 Department of Biology, Columbia University, New York City, NY
1990 Department of Biology, Temple University, Philadelphia, PA
1989 Gordon Conference on Chronobiology, Plymouth, NH
1989 FASEB Meeting on Molecular Neurogenetics, Saxtons River, Vermont
1989 Department of Human Genetics, Yale University School of Medicine, New Haven, CT
1989 Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT
1989 Marine Biological Laboratory, Woods Hole, MA
1989 Fifteenth Biennial Fungal Genetics Conference, Asilomar, CA
1989 Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA
1989 Department of Biology, Clarkson Univ., Pottsdam, New York
1988 Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA
1988 Department of Biology, State University of New York, Albany, New York
1988 Laboratory of Plant Molecular Biology, Rockefeller University, New York, NY
1988 Meeting of the Society for Research on Biological Rhythms, Wild Dunes, NC
1988 Department of Biology, University of Virginia, Charlottesville, VA
1987 FASEB Meeting on Molecular Neurobiology, Copper Mountain, CO
1987 Gordon Conference on Chronobiology, Plymouth, NH
1986 Neurosciences Group, Department of Biology, Brandeis University, Waltham, MA
1984 National Academy of Sciences: Workshop on Nonmammalian Model Systems for Biological Regulation, Washington, D.C.
1983 Gordon Conference on Chronobiology, Colby-Sawyer College, New London, NH.
1983 Department of Biochemistry, Dartmouth Medical School, Hanover, NH
1981 Gordon Conference on Chronobiology (discussant), Andover, NH.
1981 Hopkins Marine Station, Stanford University, Pacific Grove, CA.
1980 Department of Botany, Massey University, Palmerston North, New Zealand.
1980 Department of Physics, University of Tasmania, Hobart, Tasmania, Australia.
1980 Department of Biology, University of Aukland, Auckland, New Zealand.
1980 Department of Agricultural Chemistry, Nagoya University, Nagoya, Japan.
1980 DFG Workshop on the Molecular Mechanism of the Biological Clock, Heidelberg, Federal Republic of Germany.
1980 DARPA Workshop on Bioluminescence in the Marine Environment, San Diego, CA.
MEETING AND SYMPOSIA ORGANIZATION
2007 - co-Proposer 71st Cold Spring Harbor Symposium: Circadian Rhythms
2004 - session Chair, Cellular and Molecular Mycology Gordon Conference
2000 - session Chair, Cellular and Molecular Mycology Gordon Conference
1999 - session Chair, Chronobiology Gordon Conference, Barga Italy
1999 - session Chair and convener, Int'l. Congress on Chronobiology, Washington DC
1998 Chair of the Cellular and Molecular Mycology Gordon Conference
1998 Session Chair, Society for Research on Biological Rhythms
1995 Meeting Co-Organizer, Physiology and Genetics of the Biological Clock, sponsored by the American Physiological Society
1992 Workshop Organizer, Society for Research on Biological Rhythms, Amelia Island, Fl
1991 Co-organizer, Sixteenth Biennial Fungal Genetics Meeting, Asilomar, CA
1988 Symposium Organizer, Society for Research on Biological Rhythms, Wild Dunes, NC
COURSE INVOLVEMENT
Biochemistry 61 - Molecular Genetics of Prokaryotes and Lower Eukaryotes - created course with co-instructor, taught annually, 1987 - 1992
Biochemistry 77/111 - Biochemistry I - Substantial involvement with this first term of the large, departmentally staffed 3 term course in General Biochemistry for medical students, graduate students, and undergraduates; involved since 1984, course director in 1988; taught annually with each faculty member also teaching discussion sections every other year. ended 1992
Biochemistry 79 - Biochemistry III - minor involvement (four to six contact hours per term) in this third term of the 3 term course in Biochemistry; third term geared primarily for graduate students, and undergraduates ; involved in 1985, 1986, and 1987 only
Biochemistry 87 - Undergraduate Research - seven undergraduate students have/are learning the basics of research by working in our lab
Maternal and Child Health 100 - Human Genetics (minor involvement in shared course), 1992-4
Biochem 101 - Introductory graduate level course in molecular biology; began in 1992 (shared course)
Biochemistry 118 - Regulation of Gene Expression - advanced topic, mixed seminar/lecture type course offered primarily for graduate students and senior undergraduates; annual
Biochemistry 135 - Graduate student lab rotations during year one of graduate school; numerous students have been involved in this in our lab
Biochemistry 137 - Project Research - for graduate students during the time interval between the end of year one and completion of the qualifying exam; have supervised seven students
Biochemistry 144/Physiology 144 - Current Topics in Cellular Physiology (minor involvement in shared course)
Biochemistry 151 - Molecular and Cellular Neuroscience - introductory genetic and molecular neuroscience course taught to graduate students from multiple departments; lecturing on biology, genetics, and molecular genetics of circadian rhythms in vertebrate and invertebrate systems (minor involvement in shared course)
Biochemistry 157 - Thesis Research - for graduate students following the qualifying exam
Psychology 50 - Issues in Neuropsychology: Sleep and Sleep Disorders (minor involvement in shared course)
Genetics 101 -Introductory graduate level course in genetics and molecular biology
Genetics 142 (Bio 79) - Behavioral Genetics
STUDENTS SUPERVISED
Graduate students -
Keith Johnson - postdoc with Janet Bramm, Rice University, now working in industry
Kristin Lindgren - postdoc with Russell Fernald at Stanford, now taking time off
Qiuyun Liu - Senior Research Associate, Guangzhou, PRC
Norman Garceau – Laboratory Director, Pfizer Central Research, Cambridge,MA
Chenghua Luo - postdoctoral fellow, Yale University
Anne Cole - graduate student, transferred to University of Utah, now PhD, doing high school genetics web-based curricula
Allan Froehlich – postdoctoral fellow, with Bob Horwitz, MIT
Antonio Pregueiro – just finished
Mi Shi – current
Chris Baker– current
Chen-Hui Chen– current
Postdoctoral students -
C. Robertson McClung - Professor of Biology, Dartmouth College
Jennifer J. Loros, Professor of Biochemistry, Dartmouth Medical School
Benjamin Aronson - Associate Professor at Redlands College
Ann Lichens-Park - Director of two competitive grants divisions at USDA
Deborah Bell-Pedersen - Associate Professor, Texas A&M
Martha Merrow - Senior Research Associate in the Dept. of Physiological Medicine, Ludwig-Maximilians-University, Munich, FRG
Susan Crosthwaite - lecturer (Ass't. Prof.) at Univ. Manchester, UK)
Hyeseon Cho - senior research associate at NIH
Mari Shinohara - Lab Chief, Novo Nordsk, Tokyo; now senior staff, Dana Farber Cancer Center, Boston
Yi Liu - Associate Professor, Univ. Texas Southwestern, Dallas, TX
Jill Wahleithner –Biotech analyst for venture capital firm, Washington
Gloria Berrocal Tito- senior staff, CNRS, Paris
Michael Collett – laboratory director, Dairy Research Inst., Palmerston North, New Zealand
Christian Heintzen - lecturer (Ass't. Prof.) at Univ. Manchester, UK)
Jonathan Best – laboratory director, Merck, United Kingdom
Deanna Denault – Professor in General Education, New Hampshire Community Technical College
Kwangwon Lee – Ass’t Prof., Dept. Plant Pathology, Cornell University
Giles Duffield – Borroughs –Wellcome Fellow, Imperial College, London
Minou Nowrousian – Privat Docent (Ass’t Prof.), Ruhr-Universität Bochum, Bochum, Germany
Chris Pitt – laboratory manager, MRC, United Kingdom
Han Cho – doing second postdoc with Ron Evans, San Diego
Arun Mehra – current
Carsten Schwerdtfeger – current
William Belden - current
Luis Larrondo - current
Chris Hong – current
Josh Gamsby – current
Patrick Collopy - current
RESEARCH ACTIVITIES
Areas of Research: Molecular Basis of Circadian Rhythms, Fungal Genetics
Research Support (direct costs only):
Past
P.I. "Molecular Genetic Analysis of Circadian Rhythms"; Charles E. Culpeper Foundation; 4/1/85 - 12/31/86; Total, $28,335
P.I. "Genetic and Molecular Dissection of the Neurospora Clock"; American Cancer Society Institutional Research Grant; 8/14/84 - 6/30/85; Total, $4300
P.I. "Identification of a Circadian Clock-Critical Protein"; Hitchcock Foundation; 10/1/84 - 9/30/85; Total, $3250
P.I. "Isolation of a Circadian Clock-Critical Protein"; National Science Foundation grant number DMB-8417810; 7/15/85 - 12/31/88; Total, $172,670
P.I. "Genetic and Molecular Dissection of the Neurospora Clock"; NIGMS R01 GM34985 01-03; 2/01/86 - 7/15/89; Total $276,260
Co-P.I "Molecular Mechanisms of Circadian Clock Control"; National Science Foundation grant number DMB-8819957; 11/15/88 - 6/30/92; Total $184,550
P.I. "Fungal Genetics Conference"; NSF DMB-9020540; 3/1/91 - 3/1/92; Total $7,000
P.I. "Identification and Analysis of Circadian Clock-Controlled Genes"; NIMH R01 MH44651 01-03; 9/1/89 - 12/31/93; Total $349,430
P.I. "Genetic and Molecular Dissection of the Neurospora Clock"; NIGMS R01 GM34985 04-08; 7/01/89 - 6/30/94; Total $ 669,690 (15 percentile)
P. I. "Genetic and Molecular Dissection of the Neurospora Clock"; NIGMS R01 GM34985 09-014; 7/01/94 - 6/30/98; Total $ 692,302. 15th percentile score.
P.I. "Identification and Analysis of Circadian Clock-Controlled Genes"; NIMH R01 MH44651 04 - 09; 1/1/93 - 12/31/97 Total $675,249, (2.6 percentile)
Present
P.I. "Identification and Analysis of Circadian Clock-Controlled Genes"; NIMH R01 MH44651 14-19; 1/1/03 - 12/31/07 First year $435,739(5th percentile). This grant has focused for the past 15 years on analysis of clock output, how circadian oscillators control gene expression and metabolism in living cells. The emphasis is now on the model system Neurospora and on mammalian cells in culture.
P. I. "Genetic and Molecular Dissection of the Neurospora Clock"; NIGMS R37 GM34985 13 - 17; 7/01/98 - 6/30/08; MERIT Award. present year $ 378,465 (5th percentile score). This effort has focused for the past 16 years on the molecular mechanism of eukaryotic circadian oscillators and the means through which they are reset by environmental cues.
Project Number NIGMS1P01 GM 068087-01 4/1/04 – 3/31/09
PI – “NIH Program Project Functional Analysis of a Model Filamentous Fungus”
Total budget for entire grant: Year 1 $2,534,167, over 5 years, $9,012,436
Also PI on SubProject #1 Systematic Gene Knockouts” – $378,794 year 1, 20 % Effort
The major goals of this Program Project are to develop gene disruptions for half the genes in Neurospora, a method for web-based community annotation, oligo based chips for transcriptional profiling,, ESTs, and a SNP map. 8 institutions and 11 PIs are participating.
PATENTS ISSUED
Title: Methods for regulating gene expression using light
patent number 6733996 Issued 5/11/04
PUBLIC SPEAKING/POPULARIZATION OF SCIENCE: Our research findings have been aired by personal interview or been the focus of specifically targeted pieces in the following venues
Valley News - March 1994
Valley News - June 30, 1995
BBC World News - March 1994
Voice of America - July 7, 1995
WMUC (Manchester, NH) - July 5, 1995
interviewed extensively for Dallas Morning News
radio interview KTSA, San Antonio, January 1, 1995
THE PATRIOT LEDGER (Boston) August 8, 1995
SCIENCE NEWS August 12, 1995
NATURE (News and Views) July 27, 1995
THE CHRONICLE OF HIGHER EDUCATION August 18, 1995 (cover story)
Journal of NIH Research, January 1996
The Scientist, December 1995
Science - 1996 - 3 times
The Economist, March 1997
WNWU (Evanston, IL) May 1997
Science - 1997 - 2 times
Cell - July 1997
Current Biology -August, 1997
Reuters, CNN, 2 radio interviews, Washington Post, August 1998
BBC radio interview - Sept. 1999
[[[Not updated since 1999; these average one to three per year]]]
COMMUNITY SERVICE
Board member Thetford After School Program, 1995 - 1999
Trustee, First Congregational Church in Thetford, UCC 1990 - 1995
Moderator, First Congregational Church in Thetford, UCC, 1992-1997
Board of Pastoral Relations, 1998 - 2004, chair 2000 – 2004, Deacon 2005 -
2003- Co-chair, "Open to All" Capital Campaign to make Thetford Meeting House handicapped-accessible
2004 Volunteer instructor, "Human Genetics" for "Thetford Reads"
PUBLICATIONS
Books
Chronobiology: Biological Timekeeping, 382 pages, 278 illustrations, ISBN 0-87893-149-X, written and/or edited by Jay C. Dunlap, Jennifer J. Loros, and P. J. DeCoursey, April 2003, Sinauer Associates. This is a textbook on circadian biology, the first to be published in 18 years. Chapters cover all aspects of chronobiology ranging from mathematical analysis of oscillators through photoperiodism and circannual rhythms to rhythms-related aspects of human psychiatry.
Advances in Genetics, volumes 32 through 47, co-edited with Jeff Hall
Invited Reviews and Chapters in books:
Dunlap, J. C., Taylor, W. and Hastings, J. W. 1981. The control and expression of bioluminescence in dinoflagellates. In: Bioluminescence (K. H. Nealson, ed.), pp. 108-124, Burgess Publ. Co., Minneapolis.
Krasnow, R., Dunlap, J. C., Taylor, W. R., Hastings, J. W., Vetterling, W. and Haas, E, 1981. Measurements of Gonyaulax bioluminescence, including that of single cells. In: Bioluminescence (K. H. Nealson, ed.), pp. 52-65, Burgess Publ. Co., Minneapolis.
Hastings, J. W., Dunlap, J. C. and Taylor, W. R. 1981. Biochemical analysis of circadian clocks. In: Current Topics in Metabolic Regulation, vol. 18 (B. Horecker and E. Stadtman, eds.), pp. 519-529, Academic Press, New York.
Hastings, J. W. and Dunlap, Jay. C. 1986. Cell free components in dinoflagellate bioluminescence. Methods in Enzymology 133: 307-327.
Dunlap, Jay C. and Jennifer, J. Loros. 1990. Genetics and Molecular Genetics of the Circadian Biological Clock in Neurospora , Seminars in Developmental Biology 1: 221-232.
Dunlap, Jay C., Qiuyun Liu, Keith Johnson, and Jennifer J. Loros. 1992. Molecular Genetics of the Neurospora Biological Clock, invited review for the book Molecular Genetics of Biological Rhythms (Michael Young, ed.) pp. 37 - 54.
Loros, Jennifer, J., Kristin M. Lindgren, Ann Lichens-Park and Jay C. Dunlap. 1992. Molecular Genetic Analysis of Clock-Controlled Genes in Neurospora, invited review for the book Molecular Genetics of Biological Rhythms (Michael Young, ed) pp. 55 - 72.
Dunlap, Jay C. 1992. Analysis of Control Elements and Controlled Elements in the Neurospora Clock System, In: Discussions in Neuroscience 8: 84 - 88.
Dunlap, Jay C. 1992. Genetic and Molecular Dissection of the Neurospora Circadian System, In: Biological Clocks- from Cell to Human (Hiroshige, T. and Honma, K., eds) Hokkaido University Press, Sapporo, Japan, pp. 3 - 18
Dunlap, Jay C., Jennifer J. Loros, Benjamin D. Aronson, Keith A. Johnson, Qiuyun Liu, Kristin M. Lindgren, Deborah Bell-Pedersen, and Norman Garceau. 1992. Genetic and Molecular Analysis of the Neurospora Circadian Clock, In: Molecular Biology of Filamentous Fungi, (Tudzynski, P. and Stahl, U., Verlag Chemie, eds.) Berlin, pp. 253 - 265.
Aronson, B.D., Keith A. Johnson, Qiuyin Liu, and Jay C. Dunlap. 1992. Molecular Analysis of the Neurospora Clock: Cloning and characterization of the frequency and period-4 genes. Chronobiology International 9: 231 - 239.
Dunlap, Jay C. Genetic Analysis of Circadian Clocks. 1993. Annual Review of Physiology 55, 683 - 728.
Dunlap, Jay C., Jennifer J. Loros, Benjamin D. Aronson, Keith A. Johnson, Qiuyun Liu, Kristin M. Lindgren, Deborah Bell-Pedersen, and Norman Garceau. Genetic and Molecular Analysis of the Neurospora Clock. 1993. Brain Research Reviews18, 329 - 330.
Dunlap, Jay C. Jennifer J. Loros, Benjamin Aronson, Martha Merrow, Susan Crosthwaite, Deborah Bell-Pedersen, Kristin Lindgren, Norman Y. Garceau and Keith Johnson. 1994. Genetic Basis of the Circadian Clock, In: Circadian Clocks and Their Adjustment, ( J. Waterhouse, ed.) Wiley, Chichester. Ciba Foundation Symposium No. 183, pp. 3 - 25.
Jay C. Dunlap, Jennifer J. Loros, Martha Merrow, Susan Crosthwaite, Deborah Bell-Pedersen, Norman Garceau, Mari Shinohara, Hyeseon Cho, and Chenghua Luo. 1996. The Genetic and Molecular Dissection of a Prototypic Circadian System, In: Progress in Brain Research, (R.M. Buijs, A. Kalsbeck, H. J. Romijn, C. M. A. Pennartz, and M. Miriman, eds.) Elsevier, Amsterdam, Progress in Brain Research 111: 11 - 27.
Dunlap, Jay C. Genetic and Molecular Analysis of Circadian Rhythms, Annual Review of Genetics 30: 579 - 601, 1996.
Jennifer J. Loros, Jay C. Dunlap, Susan Crosthwaite, Deborah Bell-Pedersen, Norman Garceau, Mari Shinohara, Hyeseon Cho, and Chenghua Luo, Yi Liu, Michael Collett, Anne Cole, Christian Heintzen and Martha Merrow. 1996. Light, Light Responsive Genes, and the Mechanism of the Circadian Clock in Neurospora, In: Landmarks in Photobiology from Proceedings of the 12th International Congress on Photobiology , pp. 129-133.
Dunlap. Jay C. 1998. Biological Clocks, In: The McGraw Hill Yearbook of Science and Technology, ( S. Parker, ed.) McGraw Hill, New York, pp. 21 - 24.
Dunlap, J. C., Loros, J. J., Crosthwaite, S., Liu, Y., Garceau, N. Y., Bell-Pedersen, D., Shinohara, M., Luo, C., Collett, M., Cole, A. & Heintzen, C. 1998. The Circadian Regulatory System in Neurospora. In: Microbial Responses to Light and Time (D. Roberts, ed.) pp. 279 - 294, Cambridge: Cambridge Univ. Press.
Dunlap, Jay C. 1998. Clock genes and temperature effects: how to build a cellular oscillator. NeuroReport 9: 9
Dunlap, Jay C. 1998. Common Threads in Eukaryotic Rhythms Research. Curr. Opinions in Genetics and Developmental Biology 8: 400-406.
Dunlap, Jay C. 1998. An end in the beginning. Science 280: 1548 - 1549.
Dunlap, Jay C., Loros, J. J., Liu, Y., Crosthwaite, S.1999. Eukaryotic Circadian Systems: Cycles in Common, Genes to Cells 4, 1-10.
Dunlap, Jay C. Molecular Bases of Circadian Oscillators. 1999. Cell96: 271 - 290
Liu, Y., Heintzen, C., Loros, J. J., and Dunlap, Jay C. 1999. Regulation of Clock Genes, Cellular and Molecular Life Sciences 55, 1195 - 1205.
Dunlap, Jay C., Jennifer J. Loros. 2001. Molecular Genetics of Circadian Rhythms in Neurospora, In: Handbook of Behavioral Neurobiology, (Takahashi, J. Turek, F.W. and Moore, eds.) R.Y. Plenum Press, New York.
McWatters H, Dunlap JC , Millar A. 1999. Clocks for the real world. Curr Biol. 9: 633-635.
Iwasaki, H. and Jay C. Dunlap. 2000. Microbial Circadian Oscillatory Systems in Neurospora and Synechococcus: Models for Cellular Clocks, Curr. Opin. Micro. 3, 189 - 196.
Dunlap, J.C. (2000) A new slice on an old problem. Nature Neurosci. 3, 305 - 306.
Dunlap, J.C. (2001) Neurospora circadian clocks. Encyclopedia of Life Sciences, published online by Nature at http://www.els.net/els/els/els/index.html
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Loros,J. J. and J. C. Dunlap (2001) Genetics and Molecular Genetics of the Neurospora Circadian System. Ann. Rev. Physiol. 63, 757 - 794.
Nowrousian, M., Nelson, M. A. and J. C. Dunlap. 2004. Functional Genomics and Transcriptomics, In The Mycota II, U. Kuck (ed). Springer-Verlag, Berlin., pp. 115 - 127.
Froehlich, A. F., Pregueiro, A., Lee, K., Denault, D., Colot, H., Nowrousian, M., Loros, J. J. and J. C. Dunlap. 2003. The Molecular Workings of the Neurospora Clock. Novartis Found Symp. 253:184-98
Dunlap, J.C. 2004. The Molecular Mechanism of Circadian Oscillators, In Chronobiology: Biological Timekeeping. Sinauer Associates, pp. 212 - 253.
Dunlap, J. C., Loros, J. J., Denault, D., Lee, K., Froehlich, A. F., Colot, H., Shi, M., Pregueiro, A., Ruoff, P. 2005. Molecular and genetic analysis of the Neurospora circadian clock- An Overview, In The Circadian Clock in Eukaryotic Microorganisms, F. Kippert (ed). Landes Bioscience/Eurekah, in press
Dunlap, Jay C. and Jennifer J, Loros. Molecular and Genetic Analysis of Circadian Rhythms. invited review for Microbiological Reviews. to be completed in 2004
Dunlap, J. C., Loros, J. J., Denault, D., Lee, K., Froehlich, A. F., Colot, H., Shi, M., Pregueiro, A., Ruoff, P. 2004. Genetics and Molecular Biology of Circadian Rhythms, In The Mycota III, 2nd. Ed., Biochemistry and Molecular Biology, ed. R. Brambl and G. A. Marzluf, Springer-Verlag, Berlin., pp. 209 - 229.
Dunlap, J. C. 2006. Blue Light Photoreceptors - beyond phototropins and cryptochromes, in Photomorphogenesis in Plants, a textbook, ed. E. Schaefer and F. Nagy, Kluwer Academic Publ., Dordrecht. in press
Dunlap, J. C. and Loros, J. J. 2005. Neurospora photoreceptors, Handbook of Photosensory Receptors, ed. W. R. Briggs and J. Spudich. Wiley-VCH, pp. 371 – 389.
Dunlap, J. C and Loros, J. J. 2004. The Neurospora circadian system. J. Biol. Rhythms. 19: 414-424.
[Dunlap, J. C. and Loros, J. J. The Neurospora circadian system. Nature Rev. Micro.. Nov, 2006.]
Dunlap, J. C. 2004. Kinases and Circadian Clocks. Dev. Cell 6, 160 - 161.
Dunlap, J. C and Loros, J. J. 2005. Analysis of circadian rhythms in Neurospora - overview of assays and genetic and molecular biological manipulation. Methods Enzymology,393, 3 – 22.
Duffield, G., Loros, J. J., and Dunlap, J. C. 2005. Analysis of circadian output rhythms of gene expression in Neurospora and mammalian cells in culture. Methods Enzymology393, 315 – 341.
Dunlap, J. C. 2006. Running a clock requires quality time together. Science 311, 184 - 186.
Peer Reviewed articles:
Applebaum, D. M., Dunlap, J. C. and Morris, D. R. 1977. Comparison of the biosynthetic and biodegradative ornithine decarboxylases of E. coli. Biochemistry 16: 1580-1584.
Dunlap, J. C., Taylor, W. R. and Hastings, J. W. 1980. The effects of protein synthesis inhibitors on the Gonyaulax clock. I. Phase shifting effects of cycloheximide. J. Comp. Physiol. 138: 1-8.
Rensing, L., Taylor, W. R., Dunlap, J. C. and Hastings, J. W. 1980. The effects of protein synthesis inhibitors on the Gonyaulax clock. II. The effect of cycloheximide on ultrastructural parameters. J. Comp. Physiol. 138: 9-18.
Krasnow, R., Dunlap, J. C., Taylor, W. R., Hastings, J. W., Vetterling, W. and Gooch, V. 1980. Circadian spontaneous bioluminescent glow and flashing of Gonyaulax polyedra. J. Comp. Physiol. 138: 19-26.
Dunlap, J. C., Shimomura, O. and Hastings, J. W. 1980. Cross reactivity between the light emitting systems of distantly related organisms involving a novel type of light emitting compound. Proc. Nat. Acad. Sci. 77: 1394-1397.
Dunlap, J. C. and Hastings, J. W. 1981. Biochemistry of dinoflagellate bioluminescence: Purification and characterization of dinoflagellate luciferin from Pyrocystis lunula. Biochemistry 20: 983-989.
Dunlap, J. C. and Hastings, J. W. 1981. The biological clock in Gonyaulax controls luciferase activity by regulating turnover. J. Biol. Chem. 256: 10509-10518.
Dunlap, J. C., Hastings, J. W. and Shimomura, O. 1981. Dinoflagellate luciferin is structurally related to chlorophyll. FEBS Letters 135: 273-276.
Taylor, W. R., Dunlap, J. C. and Hastings, J. W. 1981. Inhibitors of protein synthesis on 80S ribosomes phase shift the Gonyaulax clock. J. Exp. Biol. 97: 121-136.
Taylor, W. R., Krasnow, R., Dunlap, Jay. C., Broda, H. and Hastings, J. W. 1982. Critical pulses of anisomycin drive the circadian oscillator in Gonyaulax towards its singularity. J. Comp. Physiol. 148: 11-25.
Feldman, J. F. and Dunlap, Jay. C. 1983. Neurospora crassa: A unique system for studying circadian rhythms. Photochem. Photobiol. Revs. 7: 314-368.
Dunlap, J. C. and Feldman, J. F. 1988. On the Role of Protein Synthesis in the Circadian Clock of Neurospora. Proc. Nat. Acad. Sci. USA 85: 1096-1100.
Liu, Q. and Dunlap, Jay C. 1988. A Rapid and Efficient Approach for Neurospora Transformation. Fungal Genetics Newsletter 35, 24-25.
McClung, R. and Dunlap, Jay C. 1988. A Modified Dot-Blot Hybridization Protocol for Filamentous Fungi. Fungal Genetics Newsletter 35, 26-27.
McClung, R., Phillips, J., Orbach, M. and Dunlap, Jay C. 1989. New Cloning Vectors Using Benomyl Resistance as a Dominant Selectable Marker for Selection in Neurospora and other Filamentous Fungi. Experimental Mycology 13, 299 - 302.
Loros, J.J., Denome, S. and Dunlap, Jay C. 1989. Molecular Cloning of Genes under Control of the Circadian Clock in Neurospora. Science 243, 385 - 388.
McClung, C.R., Fox, B.A., and Jay C. Dunlap. 1989. The Neurospora Clock Gene frequency Shares a Sequence Element with the Drosophila Clock Gene period. Nature 339, 558 - 562 (cover article)
Dunlap, Jay C. 1990. Closely Watched Clocks: Molecular Analysis of Circadian Rhythms in Neurospora and Drosophila. Trends in Genetics 6, 159 - 165 (cover article).
Lindgren, K., Lichens-Park, A., Jennifer J. Loros, and Jay C. Dunlap. 1990. A Quick RNA Miniprep for Neurospora Mycelial Cultures. Fungal Genetics Newsletter 37, 21 - 23.
Loros, Jennifer, J. and Jay C. Dunlap. 1991. Neurospora Clock-Controlled genes are Regulated at the Level of Transcription. Molecular and Cellular Biology 11, 558 - 563.
Bell-Pedersen, D., Dunlap, Jay C. and Jennifer J. Loros. 1992. The Neurospora circadian clock-controlled gene ccg-2 is allelic to eas and encodes a fungal hydrophobin required for formation of the conidial rodlet layer. Genes and Development 6, 2382 - 2394.
Arpaia, G. Loros, J.J., Dunlap, Jay C., Morelli, G. and G. Macino. 1993. The Interplay of Light and the Circadian Clock: Independent Dual Regulation of the Clock-Controlled Gene ccg-2. Plant Physiology 102, 1299 - 1305.
Aronson, B.D., Lindgren, K.M., Dunlap, Jay C. and Jennifer J. Loros. 1994. An Efficient Method for Gene Disruption in Neurospora. Molecular and General Genetics 242, 490-494.
Merrow, M. and Jay C. Dunlap. 1994. Intergeneric Complementation of a Circadian Rhythmicity Defect: Phylogenetic Conservation of the 989 amino acid Open Reading Frame in the Clock Gene Frequency, EMBO J. 13, 2257 - 2266.
Aronson, B., Johnson, K., and Jay C. Dunlap. 1994. The circadian clock gene frequency: a single ORF defines period length and temperature compensation, Proc. Nat. Acad. Sci. USA, 91, 7683 - 7687.
Aronson, B., Johnson, K., J. Loros, and Jay C. Dunlap. 1994. Negative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency, Science, 263, 1578 - 1584 (cover article).
Arpaia, G. Loros, J.J., Dunlap, Jay C., Morelli, G. and G. Macino. 1995. The Clock-Controlled Gene ccg-1 is Independently Transcriptionally Induced by Light. Molecular and General Genetics 247, 157 -163
Crosthwaite, S., Loros, J. J. and Jay C. Dunlap. 1995. Light-Induced Resetting of a Circadian Clock is Mediated by a Rapid Increase in frequency Transcript, Cell 81, 1003 - 1012 (cover article)
Liu, Q. and Jay C. Dunlap. 1996. Molecular analysis of the arg-13 locus of Neurospora , Genetics 143, 1163 - 1174.
Bell-Pedersen, D., Dunlap, Jay C. and Jennifer J. Loros. 1996. Distinct cis-acting elements mediate clock, light, and developmental regulation of the Neurospora crassa eas (ccg-2) gene. Molecular and Cellular Biology 16, 513 - 521.
Bell-Pedersen, D., Shinohara, M., Loros, J., and Jay C. Dunlap. 1996. Circadian clock-controlled genes isolated from Neurospora crassa are late night- to early morning-specific. Proc. Nat. Acad. Sci. USA 93, 13096 - 13101, 1996.
Merrow, M., Garceau, N., and Jay C. Dunlap. 1997. Dissection of a circadian oscillation into discrete domains. Proc. Nat. Acad. Sci. USA 94, 3877 - 3882.
Garceau, N., Liu, Y. Loros, Jennifer J. and Jay C. Dunlap. 1997. Alternative initiation and time-specific phosphorylation reflect complex regulation of the circadian clock protein FREQUENCY. Cell 89, 469 - 476.3
Liu, Y., Garceau, N., Loros, Jennifer J. and Jay C. Dunlap. 1997. Thermally regulated translational control mediates aspects circadian temperature responses in the Neurospora circadian clock. Cell, 89, 477 - 486.3
Crosthwaite, S., Dunlap, Jay C. and Jennifer J. Loros. 1997. Neurospora wc-1 and wc-2: Transcription, Photoresponses, and the Origins of Circadian Rhythmicity. Science 276, 763 - 769.4
Shinohara, M., Loros, Jennifer J. and Jay C. Dunlap. 1998. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is regulated on a daily basis by the circadian clock. J. Biol. Chem. 273, 446 - 452.
Luo, C., Loros, J. J., and Jay C. Dunlap. 1998. Nuclear Localization is Required for Function of the Essential Clock Protein FREQUENCY. EMBO J. 17, 1228 - 1235.
Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takeida, S., Yan, L., Tei, H., Moriya, S., Shibata, S., Loros, J. J. , Dunlap, J. C. and Okamura, H. 1997. Light-induced Resetting of a Mammalian Circadian Clock is Associated with Rapid Induction of the mPer1 Transcript. Cell 91, 1043 - 1053.
Liu, Y., Merrow, M., Loros, J. J. and Jay. C. Dunlap. 1998. How Temperature Changes Reset a Circadian Oscillator, Science 281, 825 - 829.
Liu, Y., Loros, J. J. and Jay. C. Dunlap. 2000 .Phosphorylation of the Neurospora clock protein FREQUENCY determines its turnover rate and sets the period of the circadian clock, Proc. Nat. Acad. Sci. USA. 97, 234 - 239.
Yagita, K. Yamaguchi, S., Gijsbertus, S., van der Horst, T.J., Hoeijmakers,J H., Yasui, A., Loros, J. J., Dunlap, J. C., and Okamura, H. 2000. Dimerization and nuclear entry of mPER proteins in mammalian cells, Genes & Development 14, 1353 - 1363.
Lee, K., Loros, J. J. and Jay C. Dunlap. 2000. Interconnected feedback loops in the Neurospora circadian system, Science 289, 107 - 110.
Collett, M. A. , Dunlap, J. C. and Loros, J. J. 2000. Partially functional WHITE COLLAR-2 gives reduced levels of frequency transcript and protein, lengthened period and altered temperature compensation of the Neurospora circadian clock. Molec. Cell. Biol. 21, 2619-2628.
Collett, M. A. , Loros, J. J. and Dunlap, J. C. 2001. The clock affecting-1 mutation in Neurospora is a reoccurrence of the frq7mutation. Fungal Genet. Newsl. 48, 7-9..
Denault, D., Loros, J. J. and Dunlap, J. C. 2001. WC-2 mediates WC-1:FRQ interaction within the PAS protein linked circadian feedback loop of Neurospora, EMBO J. 20, 109 – 117.
Heintzen, C., Loros, J. J. and Dunlap, J. C. 2001.The PAS protein VVD defines a clock-associated feedback loop that represses light input, modulates gating and regulates clock resetting, Cell, 104, 453–464.5
Zhu, H., Nowrousian, M., Kupfer, D., Colot, H.V., Berrocal-Tito, G., Lai, H., Bell-Pedersen, D., Roe, B. A., Loros, J. J., and Dunlap, J.C. 2001. Analysis of ESTs from two time of day-specific libraries of Neurospora crassa reveals novel clock-controlled genes, GENETICS, 157, 1057 – 1065.
Bell-Pedersen, D., Lewis, Z. A., Loros, J. J. and Dunlap, J. C. 2001. The Neurospora circadian clock regulates a transcription factor that controls rhythmic expression of the output eas(ccg-2) gene. Molec. Microbiol. 41, 897 – 909
Collett, M.A., Garceau, N., Dunlap, J. C. and Loros, J. J. 2002. Light and clock expression of the Neurospora clock gene frequency is differentially driven by but dependent on WHITE COLLAR-2. Genetics 160, 149-158
Shinohara, M. L., Correa, A., Bell-Pedersen, D., Dunlap, J. C., and Loros, J. J. 2002. Neurospora clock-controlled gene-9 (ccg-9) encodes trehalose synthase: Circadian regulation of stress responses and development. Eukaryotic Cell, 1, 33-43.
Duffield, G. E., Best, J. D., Meurers, B. H., Bittner, A., Loros, J. J. and Dunlap, J. C. 2002.Daily programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of circadian mammalian gene expression. Curr. Biol. 12, 551 – 557. (cover article)
Froehlich A. C., Liu, Y., Loros, J. J., and Dunlap J.C. 2002. White Collar-1, a circadian blue light photoreceptor, binding to the frequency promoter. Science 297, 815-8196(cover article)
Lee K, Dunlap J. C., Loros J. 2003 Roles for WHITE COLLAR-1 in Circadian and General Photoperception in Neurospora crassa. Genetics. 163, 103-14.
Nowrousian, M., Duffield, G., Loros, J. J. and Dunlap, J. C. 2003 The frequency gene is required for temperature-dependent regulation of many clock-controlled genes in Neurospora crassa GENETICS 164, 922-933.
Froehlich A. C., Loros, J. J., and Dunlap J. C. 2003. Rhythmic Binding of a WHITE COLLAR Containing Complex to the frequency Promoter is Inhibited by FREQUENCY. Proc. Nat. Acad. Sci. USA100, 5914 - 5919.
Kramer C, Loros JJ, Dunlap JC, Crosthwaite, S.K. 2003. Role for antisense RNA in regulating circadian clock function in Neurospora crassa. Nature 421, 948-952.
Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, Butler J, Endrizzi M, Qui D, Ianakiev P, Bell-Pedersen D, Nelson MA, Werner-Washburne M, Selitrennikoff CP, Kinsey JA, Braun EL, Zelter A, Schulte U, Kothe GO, Jedd G, Mewes W, Staben C, Marcotte E, Greenberg D, Roy A, Foley K, Naylor J, Stange-Thomann N, Barrett R, Gnerre S, Kamal M, Kamvysselis M, Mauceli E, Bielke C, Rudd S, Frishman D, Krystofova S, Rasmussen C, Metzenberg RL, Perkins DD, Kroken S, Cogoni C, Macino G, Catcheside D, Li W, Pratt RJ, Osmani SA, DeSouza CP, Glass L, Orbach MJ, Berglund JA, Voelker R, Yarden O, Plamann M, Seiler S, Dunlap J, Radford A, Aramayo R, Natvig DO, Alex LA, Mannhaupt G, Ebbole DJ, Freitag M, Paulsen I, Sachs MS, Lander ES, Nusbaum C, Birren B. 2003.The genome sequence of the filamentous fungus Neurospora crassa. Nature. 422, 859-868.
Borkovich KA, Alex LA, Yarden O, Freitag M, Turner GE, Read ND, Seiler S, Bell-Pedersen D, Paietta J, Plesofsky N, Plamann M, Goodrich-Tanrikulu M, Schulte U, Mannhaupt G, Nargang FE, Radford A, Selitrennikoff C, Galagan JE, Dunlap JC, Loros JJ, Catcheside D, Inoue H, Aramayo R, Polymenis M, Selker EU, Sachs MS, Marzluf GA, Paulsen I, Davis R, Ebbole DJ, Zelter A, Kalkman ER, O'Rourke R, Bowring F, Yeadon J, Ishii C, Suzuki K, Sakai W, Pratt R. 2004. Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev. 68,1-108.
Christensen, M. K.,Falkeid, G., Loros, J. J., Dunlap, J. C., Lillo, C., and Ruoff, P. 2004. A nitrate induced frq-less oscillator in Neurospora crassa. J. Biol. Rhythms 19: 280-286.
Pregueiro, A. M., Price-Lloyd, N., Bell-Pedersen, D., Heintzen, C., Loros, J. J., Dunlap, J. C. 2005. Assignment of an essential role for the Neurosporafrequency gene in circadian entrainment to temperature cycles. Proc. Nat. Acad. Sci. USA, 102, 2210 – 2215 (featured on the cover).
Nowrousian M, Ringelberg C, Dunlap JC, Loros JJ, Kuck U. 2005. Cross-species microarray hybridization to identify developmentally regulated genes in the filamentous fungus Sordaria macrospora. Mol Genet Genomics 273, 137 – 149.
Pregueiro, A. M., Price-Lloyd, N., Bell-Pedersen, D., Heintzen, C., Loros, J. J., Dunlap, J. C. 2005. Assignment of an essential role for the Neurosporafrequency gene in circadian entrainment to temperature cycles. Proc. Nat. Acad. Sci. USA, 102, 2210 – 2215 (featured on the cover).
Elvin, M., Loros,, J. J., Dunlap, J. C., and Heintzen, C. 2005. The Neurospora protein VIVID controls a rapidly dampened daytime oscillator which controls phase and entrainment of Neurospora’s clock. Genes & Dev.19:2593-2605.
Colot, H. C., Loros, J. J. and Dunlap, J. C. 2005. Temperature-modulated alternative splicing and promoter use in the circadian clock gene frequency. Mol. Biol. Cell, 16:5563-5571 (selected by the Editors for Incytes)
Ruoff, P., Loros, J. J., and Dunlap, J. C. 2006. The Relationship Between FRQ-protein stability and Temperature Compensation in the Neurospora circadian Clock. Proc. Nat. Acad. Sci. USA, 102:17681-17686.
Duffield, G. E., Watson, N. P., Mantani, A., Peirson, S. N., Loros, J. J., Israel, M. A. and Dunlap, J. C. 2006. A role for the Id2 gene in regulating photic entrainment of the mammalian circadian system; under review
Pregueiro, A. M., Liu, Q., Loros, J. J., Dunlap, J. C. 2006. Clock Gene prd-4 is the Neurospora Checkpoint Kinase 2: a Regulatory Link between the Circadian and Cell Cycles. Science
Other Publications:
Dunlap, J. C. (Project Director, NSF Student Originated Studies Grant). 1973. Environmental effects of pollution control measures undertaken by two Puget Sound paper mills: Evaluation, Recommendations, and Technical Report, Dept. Oceanography, Univ. Washington, 120 pp.
Dunlap, J. C. Book Review: Cellular and Molecular Bases of Biological Clocks by Leland Edmunds, The Quarterly Review of Biology 64, 185 - 186, 1989.
Dunlap, J. C. Book Review: Biochemical Oscillations and Cellular Rhythms: The Molecular Bases of Periodic and Chaotic Behaviour by Albert Goldbeter (Cambridge University Press) , in Endeavour
Dunlap, J. C. 2000.Review and Renaissance in the Kingdom Next Door. Cell 2000 103: 547
This article was also translated into Japanese in 2002 by Nakayama-Shoten and republished in Molecular Medicine.
This article was highlighted in a separate PERSPECTIVES published in the same issue.
2This article was also covered in a News and Views published in Nature in the July 27 1995 issue.
3This article was highlighted in a separate MiniReview published in the July 5, 1997 issue.
4This article was highlighted in a separate PERSPECTIVES published in the same issue.
5This article was highlighted in a News and Views published in Nature in the March 15, 2001 issue.