The munchnone employed in this work is easily prepared from ethyl phenylacetate by the following known route. (reference to this work WILL be added shortly - my appologies to the authors of the original work) Amino acid (12) is prepared in 80+% overall yield from the starting ester. In-situ dehydration is easily afforded by the action of dicyclohexyl- or diisopropyl carbodiimide, or more traditionally by an anhydride such as acetic anhydride.

 

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