Publications

1. Trumpower, B. L. (1990) "The Protonmotive Q Cycle: Coupling of Proton Translocation to Electron Transfer by the Cytochrome bc₁ Complex," J. Biol. Chem. 265, 11409-11412

2. Hunte, C., Palsdottir, H. and Trumpower, B. L. (2003) "Protonmotive Pathways and Mechanisms in the Cytochrome bc₁ Complex," FEBS Letts. 545, 39-46

3. Denke, E., Merbitz-Zahradnik, T., Hatzfeld, O. M., Snyder, C., Link, T. A. and Trumpower, B. L. (1998) "Alteration of the Midpoint Potential and Catalytic Activity of the Rieske Iron-Sulfur Protein by Changes of Amino Acids Forming Hydrogen Bonds to the Iron-Sulfur Cluster," J. Biol. Chem. 273, 9085-9093

4. Snyder, C. H., Merbitz-Zahradnik, T., Link, T. A. and Trumpower, B. L. (1999) "Role of the Rieske Iron-Sulfur Protein Midpoint Potential in the Protonmotive Q Cycle Mechanism of the Cytochrome bc₁ Complex," J. Bioenerg. Biomembr., 31, 235-242

5. Nett, J., Hunte, C., and Trumpower, B. L. (2000) "Changes to the Length of the Flexible Linker Region of the Rieske Protein Impair the Interaction of Ubiquinol with the Cytochrome bc₁ Complex," Eur. J. Biochem. 267, 5777-5782

6. Snyder, C. H. and Trumpower, B. L. (1999) "Ubiquinone at Center N is Responsible for Triphasic Reduction of Cytochrome b in the Cytochrome bc₁ Complex," J. Biol. Chem. 274, 31209-31216

7. Snyder, C. H., Gutierrez-Cirlos, E. B. and Trumpower, B. L. (2000) "Evidence for a Concerted Mechanism of Ubiquinol Oxidation by the Cytochrome bc₁ Complex ," J. Biol. Chem. 275,13535-13447

8. Gutierrez-Cirlos, E. B. and Trumpower, B. L. (2002) "Inhibitory Analogs of Ubiquinol Act Anti-cooperatively on the Yeast Cytochrome bc₁ Complex. Evidence for an Alternating, Half-of-the-Sites Mechanism of Ubiquinol Oxidation," J. Biol. Chem. 277,1195-1202

9. Nett, J. H. and Trumpower, B. L. (1996) "Dissociation of Import of the Rieske Iron-Sulfur Protein into Saccharomyces cerevisiae Mitochondria from Proteolytic Processing of the Presequence," J. Biol. Chem. 271, 26713-26716

10. Nett, J. H., Denke, E. and Trumpower, B. L. (1997) "Two Step Processing is Not Essential for the Import and Assembly of Functionally Active Iron-Sulfur Protein into the Cytochrome bc₁ Complex in Saccharomyces cerevisiae," J. Biol. Chem. 272, 2212-2217

11. Nett, J. H. and Trumpower, B. L. (1998) "Processing of the Presequence of the Schizosaccharomyces pombe Rieske Iron-Sulfur Protein Occurs in a Single Step and Can be Converted to Two Step Processing by Mutation of a Single Proline to Serine in the Presequence," J. Biol. Chem. 273, 8652-8658

12. Nett, J. H. and Trumpower, B. L. (1999) "Intermediate Length Rieske Iron-Sulfur Protein is Present and Functionally Active in the Cytochrome bc₁ Complex of Saccharomyces cerevisiae," J. Biol. Chem. 274, 9253-9257

13. DeLabre, M. L., Nett, J. H. and Trumpower, B. L. (1999) "The Cleaved Presequence is not Required for Import of Subunit 6 of the Cytochrome bc₁ Complex into Yeast Mitochondria or Assembly into the Complex," FEBS Letts. 449, 201-205

14. Nett, J. H., Kessl, J., Wenz, T. and Trumpower, B. L. (2001) "The AUG Start Codon of the Saccharomyces cerevisiae NFS1 Gene can be Substituted for by UUG Without Increased Initiation of Translation at Downstream Codons," Eur. J. Biochem., 268, 5209-5214

15. Lange, C, Nett, J. H., Trumpower, B. L. and Hunte, C. (2001) "Specific Roles of Protein-Phospholipid Interactions in the Yeast Cytochrome bc₁ Complex Structure," EMBO J. 20,6591-6600

16. Trumpower, B. L. (2002) "A Concerted, Alternating Sites Mechanism of Ubiquinol Oxidation by the Dimeric Cytochrome bc₁ Complex," Biochim. Biophys. Acta, 1555, 166-173

17. Gutierrez-Cirlos, E. B., Merbitz-Zahradnik, T. and Trumpower, B. L. (2002) "Failure to Insert the Iron-Sulfur Cluster into the Rieske Iron-Sulfur Protein Impairs Both Center N and Center P of the Cytochrome bc₁ Complex," J. Biol. Chem. 277, 50703-50709

18. Hill, P., Kessl, J., Fisher, N., Meshnick, S., Trumpower, B. L. and Meunier, B. (2003) "Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis carinii," Antimicrobiol. Agents Chemother. 47, 2725-2731

19. Palsdottir, H., Gomez Lojero, C., Trumpower, B. L. and Hunte, C. (2003) "Structure of the Yeast Cytochrome bc₁ Complex with a Hydroxyquinone Anion Qo Site Inhibitor Bound," J. Biol. Chem., 278, 31303-31311

20. Kessl, J. J., Lange, B. B., Merbitz-Zahradnik, T., Zwicker, K., Hill, P., Meunier, B., Hunte, C., Meshnick, S. and Trumpower, B. L. (2003) "Molecular Basis for Atovaquone Binding to the Cytochrome bc₁ Complex," J. Biol. Chem., 278, 31312-31318

21. Sun, J. and Trumpower, B. L. (2003) "Superoxide Anion Generation by the Cytochrome bc₁ Complex," Arch. Biochem. Biophys., 419, 198-206

22. Merbitz-Zahradnik, T., Zwicker K., Nett, J. H., Link, T. A. and Trumpower, B. L. (2003) "Elimination of the Disulfide Bridge in the Rieske Iron-Sulfur Protein Allows Assembly of the [2Fe-2S] Cluster into the Rieske Protein but Damages the Ubiquinol Oxidation Site in the Cytochrome bc₁ Complex," Biochemistry, 42, 13637-13645

23. Kessl, J. J., Hill, P., Lange, B. B., Meshnick, S. R., Meunier, B. and Trumpower, B. L. (2004) "Molecular Basis for Atovaquone Resistance in Pneumocystis jirovecii Modeled in the Cytochrome bc₁ Complex of Saccharomyces cerevisiae, J. Biol. Chem., 279, 2817-2824

24. Gutierrez-Cirlos, E. B., Merbitz-Zahradnik, T., and Trumpower, B. L. (2004) "Inhibition of the Yeast Cytochrome bc₁ Complex by Ilicicolin H, a Novel Inhibitor that Acts at the Qn Site of the bc₁ Complex," J. Biol. Chem., 279, 8708-8714

25. Covian, R., Gutierrez-Cirlos, E. B., and Trumpower, B. L. (2004) "Anti-cooperative Oxidation of Ubiquinol by the Yeast Cytochrome bc₁ Complex," J. Biol. Chem., 279,15040-15049

26. Kessl, J. J,. Ha, K. H., Merritt, A. K., Lange, B. B., Hill, P., Meunier, B., Meshnick, S. R. and Trumpower, B. L. (2005) “Cytochrome b Mutations that Modify the Ubiquinol Binding Pocket of the Cytochrome bc₁ Complex and Confer Anti-malarial Drug Resistance in Saccharomyces cerevisiae,” J. Biol. Chem., 280, 17142-17148

27. Covian, R. and Trumpower, B. L. (2005) “Rapid Electron Transfer Between Monomers When the Cytochrome bc₁ Complex Dimer is Reduced Through Center N,” J. Biol. Chem. 280, 22732-22740

28. Kessl, J., Ha, K. H., Merritt, A. K., Meshnick, S. R. and Trumpower, B. L. (2006) “Molecular Basis of Toxoplasma gondii Atovaquone Resistance Modeled in Saccharomyces cerevisiae,” Mol. Biochem. Parasitology, 146, 255-258

29. Covian, R. and Trumpower, B. L. (2006) "Regulatory Interactions Between Ubiquinol Oxidation and Ubiquinone Reduction Sites in the Dimeric Cytochrome bc₁ Complex," J. Biol. Chem. 281, 30925-30932

30. Ding, M., di Rago, J. P. and Trumpower, B. L. (2006) “Investigating the Qn Site of the Cytochrome bc₁ Complex in Saccharomyces cerevisiae With Mutants Resistant to Ilicicolin H, a Novel Qn Site Inhibitor,” J. Biol. Chem., 281, 36036-36043

31. Wenz, T., Covian, R., Hellwig, P., Macmillan, F., Meunier, B., Trumpower, B. L. and Hunte, C. (2007) “Mutational Analysis of Cytochrome b at the Ubiquinol Oxidation Site of Yeast Complex III,” J. Biol. Chem. 282, 3977-3988

32. Lancaster, C. R. D., Hunte, C., Kelley, J., Trumpower, B. L. and Ditchfield, R. (2007) "A Comparison of Stigmatellin Conformations, Free and Bound to the Photosynthetic Reaction Center and the Cytochrome bc₁ Complex," J. Mol. Biol. 368, 197-208

33. Kessl, J. J., Moskalev, N. V., Gribble, G. W., Nasr, M., and Trumpower, B. L. (2007) “Parameters Determining the Relative Efficacy of Hydroxynaphthoquinone Inhibitors of the Cytochrome bc₁ Complex,” Biochim. Biophys. Acta, 1767, 319-326

34. Covian, R., Kleinschroth, T., Ludwig, B. and Trumpower, B. L. (2007) “Asymmetric Binding of Stigmatellin to the Dimeric Paracoccus denitrificans bc₁ Complex: Evidence for Anti-Cooperative Ubiquinol Oxidation and Communication Between Center P Ubiquinol Oxidation Sites,” J. Biol. Chem., 282, 22289-22297

35. Covian, R., Zwicker, K., Rotsaert, F. A. and Trumpower, B. L. (2007) “Asymmetric and Redox-Specific Binding of Quinone and Quinol at Center N of the Dimeric Yeast Cytochrome bc₁ Complex: Consequences for Semiquinone Stabilization” J. Biol. Chem. 282, 24198-24208

36. Rotsaert, F. A. J., Ding, M. G. and Trumpower, B. L. (2008) “Differential Efficacy of Inhibition of Mitochondrial and Bacterial Cytochrome bc₁ Complexes by Center N Inhibitors Antimycin, Ilicicolin H, and Funiculosin,” Biochim. Biophys. Acta, 1777, 211-219

37. Rotsaert, F. A. J., Covian, R. and Trumpower, B. L. (2008) “Mutations in Cytochrome b that Affect Kinetics of the Electron Transfer Reactions at Center N in the Yeast Cytochrome bc₁ Complex,” Biochim. Biophys. Acta, 1777, 239-249

38. Covian, R. and Trumpower, B. L. (2008) “The Dimeric Structure of the Cytochrome bc₁ Complex Prevents Center P Inhibition by Reverse Reactions at Center N,” Biochim. Biophys. Acta, 1777, 1044-1052

39. Ding, M. G., Butler, C. A. Saracco, S. A., Fox, T. D., Godard, F., di Rago, J. P. and Trumpower, B. L. (2008) “Introduction of Cytochrome b Mutations in Saccharomcyes cerevisiae by a Method that Allows Selection for Both Functional and Non-Functional Cytochrome b Proteins,” Biochim. Biophys. Acta, 1777, 1147-1156

40. Covian, R. and Trumpower, B. L. (2009) “Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc₁ Complex Reveal Electron Transfer and Regulatory Interactions Between Monomers,” J. Biol. Chem. 284, 8614-8620

41. Covian, R. and Trumpower, B. L. (2008) “Regulatory Interactions in the Dimeric Cytochrome bc₁ Complex: The Advantages of Being a Twin,” Biochim. Biophys. Acta, 1777, 1079-1091

42. Ding, M. G., di Rago, J. P. and Trumpower, B. L. (2009) “Combining Inhibitor Resistance-Conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomcyes cerevisiae,” J. Biol. Chem. 284, 8478-8485

43. Covian, R. and Trumpower, B. L. (2009) “The Rate-Limiting Step in the Cytochrome bc₁ Complex (Ubiquinol-Cytochrome c Oxidoreductase) Is Not Changed by Inhibition of Cytochrome b-Dependent Deprotonation: Implications for the Mechanism of Ubiquinol Oxidation at Center P of the bc1 Complex,” J. Biol. Chem. 284, 14359-14367

44. Rottenberg, H., Covian, R. and Trumpower, B. L. (2009) “Membrane Potential Greatly Enhances Superoxide Generation by the Cytochrome bc₁ Complex Reconstituted Into Phospholipid Vesicles,” J. Biol. Chem., 284, 19203-19210